Multi-omics Metabolic & Microbiome
Profiling of Mouse Pregnancy

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Metabolic profile vs Differentially significant metabolites
Image 1

Correlation coefficients:

Body.Weight Subcutaneous.Fat Visceral.Fat Pancrease.Weight Insulin Blood.Glucose Real.HOMA.IR Serum.Acetate Serum.Butyrate Serum.Propionate Serum.Isovalerate Liver.Triglycerides
Sphingosine 1-phosphate -0.2388 -0.1954 0.0239 0.0594 0.0832 -0.1626 -0.0989 0.0045 -0.1081 0.0907 -0.2818 -0.0217
Pantetheine -0.0903 0.1658 0.176 -0.1678 0.0199 -0.2279 -0.2406 0.3091 0.5495 0.3374 0.2822 -0.0833
Inosine 0.0599 -0.2313 0.0206 0.0576 -0.1511 0.275 0.2017 0.1759 -0.0281 -0.1499 -0.3193 0.0479
Sphingosine -0.2565 0.0549 0.1176 -0.1887 0.0875 -0.1759 -0.1586 0.3717 0.5082 0.3939 0.2123 -0.1896
4,6-Dihydroxyquinoline -0.4678 -0.1834 -0.0152 -0.1818 -0.1333 -0.0853 -0.1128 0.1972 0.2762 0.523 0.2055 -0.3181
3beta-Hydroxypregn-5-en-20-one sulfate -0.3424 -0.2238 -0.2111 0.1637 -0.0691 0.2783 0.2827 -0.2341 -0.5414 -0.1765 -0.1484 -0.065
Prostaglandin G2 -0.0343 0.1146 0.121 0.0193 0.2104 -0.0898 0.0481 -0.2621 -0.2023 -0.1012 -0.1727 0.2855
L-Phenylalanine -0.6806 -0.2958 -0.0989 0.0926 -0.0204 0.1713 0.1429 -2e-04 0.0786 0.3207 0.1092 -0.2369
5-Hydroxykynurenamine -0.7663 -0.2995 -0.1208 0.1435 -0.0994 0.169 0.1258 0.0719 0.0142 0.3208 0.0878 -0.2174
Hippurate -0.3859 -0.0653 -0.0947 0.1019 0.0248 0.0968 0.0569 0.1591 0.069 0.2481 0.1125 -0.1356
Benzo[a]pyrene-7,8-diol -0.2615 -0.2006 0.1122 -0.289 -0.0629 -0.0192 -0.0672 0.1948 0.2498 0.0879 -0.0286 -0.0504
16-Glucuronide-estriol 0.103 0.0104 -0.2294 0.2669 0.1427 -0.0618 -0.0461 -0.1863 -0.1685 -0.0933 0.0079 -0.1191
S-Sulfanylglutathione 0.5336 0.412 -0.0592 0.0869 0.1974 -0.4271 -0.3653 -0.1117 0.1439 0.1174 0.101 0.1106
Estradiol-17beta 3-glucuronide 0.0542 0.1998 0.179 0.046 0.1281 0.0382 0.0448 0.1066 -0.0289 -0.1146 0.1639 0.156
L-Alanine 0.44 0.1791 -0.0043 -0.1159 0.2817 -0.1636 -0.0804 0.1106 0.2033 -0.2142 -0.074 0.1858
L-Tryptophan -0.0804 -0.1475 0.1025 -0.1984 -0.0477 0.0344 -0.0176 0.1459 0.2794 -0.123 0.1136 -0.0563
1,2-Dihydronaphthalene-1,2-diol 0.12 0.1769 0.0588 -0.2018 -0.0292 -0.238 -0.241 -0.1117 0.1684 -0.0169 0.2078 0.0999
Deoxyribose 0.0122 -0.027 0.055 0.0225 -0.1331 0.1063 0.0531 -0.0826 -0.1316 -0.239 -0.2266 -0.0136
Gentisate aldehyde 0.1432 0.0268 0.1372 -0.0809 -0.1556 0.0291 -0.032 0.0326 -0.0153 -0.0539 -0.088 -0.3147
Deoxyinosine -0.0995 -0.0514 0.0855 -0.2936 -0.0825 -0.0285 -0.0737 0.1773 0.3362 -0.0935 0.1628 -0.14
Campesterol 0.2438 -0.0082 0.0175 0.0784 -0.1544 0.0031 -0.0341 -0.2374 -0.3059 -0.1725 -0.3052 0.2962
Estrone glucuronide 0.2591 0.3044 0.0948 0.117 0.253 -0.2171 -0.1486 -0.1215 0.2019 0.1644 -0.05 0.1584
Vitamin K1 epoxide 0.5018 0.2181 0.0348 -0.2208 0.0885 -0.4052 -0.3491 0.006 0.3257 0.2328 -0.1388 0.1054
D-Fructose -0.0156 0.0882 0.1239 0.0022 -0.18 0.167 0.0919 -0.1647 -0.1771 -0.054 0.0377 0.1306
Chitin -0.295 -0.1881 -0.0201 0.1171 -0.2281 0.5241 0.452 -0.0743 -0.2117 -0.1909 0.1072 -0.0415
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane -0.3079 -0.2359 -0.2261 0.0744 -0.1455 0.2734 0.2934 -0.1221 -0.495 -0.1582 -0.1486 -0.0551
N(pi)-Methyl-L-histidine 0.1655 -0.083 -0.1012 -0.12 -0.0074 0.0916 0.1626 -0.0573 -0.1322 0.131 -0.212 0.0548
Dihomo-gamma-linolenate -0.1677 0.1259 0.0042 -0.1081 -0.2134 0.2237 0.1539 0.038 -0.1196 -0.0212 0.12 -0.0536
Taurocholate 0.543 0.6413 0.1997 -0.0016 0.1388 -0.3515 -0.2942 -0.258 0.1366 -0.1536 0.0224 0.283
Deoxyuridine 0.539 0.4618 0.0745 -0.1376 0.002 -0.2947 -0.2707 -0.1402 0.0716 0.1269 -0.1178 0.1582

P-values:

Body.Weight Subcutaneous.Fat Visceral.Fat Pancrease.Weight Insulin Blood.Glucose Real.HOMA.IR Serum.Acetate Serum.Butyrate Serum.Propionate Serum.Isovalerate Liver.Triglycerides
Sphingosine 1-phosphate 0.327 0.436 0.9413 0.8286 0.7313 0.5179 0.6902 0.9883 0.6699 0.7202 0.2008 0.9427
Pantetheine 0.7202 0.5179 0.4943 0.5179 0.9427 0.3495 0.327 0.1716 5e-04 0.1145 0.2008 0.7313
Inosine 0.8286 0.3423 0.9427 0.8297 0.5593 0.2138 0.4221 0.4943 0.925 0.5644 0.1491 0.8498
Sphingosine 0.2679 0.8297 0.6504 0.4645 0.7202 0.4943 0.5308 0.0587 0.0013 0.0347 0.3946 0.4628
4,6-Dihydroxyquinoline 0.0048 0.4849 0.9513 0.4925 0.6128 0.7267 0.6602 0.4278 0.2124 8e-04 0.4181 0.1491
3beta-Hydroxypregn-5-en-20-one sulfate 0.1059 0.3583 0.3946 0.5179 0.7846 0.2071 0.2008 0.3343 5e-04 0.4943 0.5644 0.8035
Prostaglandin G2 0.909 0.6581 0.6504 0.9427 0.3953 0.7202 0.8498 0.2558 0.4221 0.6899 0.5107 0.2008
L-Phenylalanine 0 0.181 0.6902 0.7164 0.9427 0.5147 0.5781 0.9986 0.7453 0.1491 0.6682 0.327
5-Hydroxykynurenamine 0 0.181 0.6504 0.5781 0.6902 0.5179 0.6388 0.7721 0.9548 0.1491 0.7202 0.3816
Hippurate 0.0415 0.8035 0.7101 0.6899 0.9383 0.7018 0.8297 0.5308 0.7846 0.299 0.6602 0.6018
Benzo[a]pyrene-7,8-diol 0.2558 0.4237 0.6602 0.1943 0.8146 0.9427 0.7942 0.436 0.2941 0.7202 0.925 0.8423
16-Glucuronide-estriol 0.6899 0.9701 0.3491 0.2382 0.5781 0.8193 0.8552 0.4723 0.5179 0.7146 0.9798 0.6504
S-Sulfanylglutathione 6e-04 0.0224 0.8286 0.7212 0.4278 0.0149 0.0666 0.6602 0.5781 0.6504 0.6899 0.6615
Estradiol-17beta 3-glucuronide 0.8297 0.4237 0.4943 0.8552 0.6319 0.8965 0.8602 0.6739 0.925 0.6581 0.5179 0.542
L-Alanine 0.0103 0.4943 0.9883 0.6552 0.2008 0.5179 0.7376 0.6615 0.4221 0.3946 0.7634 0.4723
L-Tryptophan 0.7376 0.5678 0.6899 0.4278 0.8498 0.909 0.948 0.5749 0.2064 0.6504 0.6602 0.8297
1,2-Dihydronaphthalene-1,2-diol 0.6504 0.4943 0.8288 0.4221 0.925 0.327 0.327 0.6602 0.5179 0.9493 0.4074 0.6902
Deoxyribose 0.9615 0.928 0.8297 0.9427 0.6128 0.6739 0.8301 0.7313 0.6166 0.327 0.352 0.9557
Gentisate aldehyde 0.5781 0.928 0.5968 0.7376 0.542 0.925 0.9165 0.9157 0.9513 0.8297 0.7202 0.1564
Deoxyinosine 0.6902 0.8386 0.7267 0.181 0.7313 0.925 0.7634 0.4943 0.1145 0.7146 0.5179 0.5905
Campesterol 0.3181 0.9798 0.948 0.7453 0.5451 0.9925 0.909 0.327 0.1716 0.5107 0.1716 0.181
Estrone glucuronide 0.263 0.1716 0.7101 0.6504 0.2815 0.3816 0.5644 0.6504 0.4221 0.5179 0.8423 0.5308
Vitamin K1 epoxide 0.0015 0.3816 0.909 0.3717 0.7202 0.0262 0.0932 0.9858 0.1418 0.338 0.592 0.6767
D-Fructose 0.9513 0.7202 0.6492 0.9933 0.4943 0.5179 0.7173 0.5179 0.4943 0.8297 0.8965 0.6172
Chitin 0.181 0.4651 0.9427 0.6504 0.3495 8e-04 0.0073 0.7634 0.3946 0.4575 0.6735 0.8796
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.1716 0.3284 0.352 0.7634 0.5749 0.2168 0.181 0.6504 0.0019 0.5308 0.5644 0.8297
N(pi)-Methyl-L-histidine 0.5179 0.7313 0.6899 0.6504 0.9799 0.7173 0.5179 0.8297 0.6162 0.6172 0.3946 0.8297
Dihomo-gamma-linolenate 0.5179 0.6388 0.9883 0.6699 0.3946 0.3583 0.5451 0.8965 0.6504 0.9427 0.6504 0.8297
Taurocholate 5e-04 0 0.4237 0.9933 0.592 0.0912 0.181 0.2645 0.5977 0.5451 0.9427 0.2008
Deoxyuridine 5e-04 0.0056 0.7634 0.5968 0.9933 0.181 0.2251 0.5905 0.7721 0.6377 0.6504 0.5308
Differentially significant microbes vs Differentially significant metabolites
Image 1

Correlation coefficients:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia
Sphingosine 1-phosphate -0.0364 -0.1404 0.1837 -0.1889 0.2797 -0.4962 0.1141 -0.0684 0 -0.3761
Pantetheine -0.0242 -0.0952 -0.0204 0.0254 -0.2207 0.2848 -0.0299 -0.1086 0 0.1298
Inosine 0.0379 -0.0158 -0.0078 0.1129 -0.2317 0.2501 0.1162 -0.0718 0 0.0213
Sphingosine -0.0043 -0.0546 -0.1431 -0.0647 -0.2966 0.2809 0.0245 -0.092 0 0.0869
4,6-Dihydroxyquinoline -0.1161 -0.0056 -0.2802 0.0079 -0.2752 0.0603 0.133 -0.0853 0 0.0733
3beta-Hydroxypregn-5-en-20-one sulfate 0.2323 -0.1957 -0.0172 -0.4317 0.424 -0.2984 0.0895 -0.0953 0 -0.2825
Prostaglandin G2 0.0475 -0.0267 0.3259 -0.2619 0.14 -0.2807 0.2013 -0.0753 0 -0.255
L-Phenylalanine -0.126 -0.1319 -0.1696 -0.3312 0.0434 -0.1024 0.021 -0.122 0 -0.0795
5-Hydroxykynurenamine -0.0932 -0.162 -0.1077 -0.4169 0.1118 -0.1503 0.0261 -0.1323 0 -0.1154
Hippurate -0.2006 -0.1476 -0.2366 -0.2071 0.1566 0.1353 -0.166 -0.0718 0 -0.0202
Benzo[a]pyrene-7,8-diol 0.0272 -0.1306 -0.003 -0.1738 -0.2578 -0.022 0.1577 0.167 0 -0.1363
16-Glucuronide-estriol 0.2006 -0.083 0.0579 0.1354 0.3192 0.0929 -0.1939 -0.1254 0 0.1751
S-Sulfanylglutathione 0.1486 0.1222 0.2268 0.4672 0.1087 0.0412 -0.2273 0.1221 0 0.323
Estradiol-17beta 3-glucuronide -0.0115 -0.0513 -0.0475 0.034 0.1233 -0.043 -0.092 -0.1086 0 -0.0939
L-Alanine -0.0184 0.1424 0.1124 0.2032 -0.268 0.2628 0.0425 0.1569 0 0.0178
L-Tryptophan 0.1427 -0.1615 -0.0056 -0.1779 -0.2536 0.0607 0.0831 0.1573 0 -0.1222
1,2-Dihydronaphthalene-1,2-diol -0.113 -0.0596 0.0899 0.0263 0.1184 0.0427 0.0259 -0.0887 0 -0.0836
Deoxyribose -0.0468 -0.0769 0.1119 -0.139 -0.0212 -0.108 0.1226 0.169 0 -0.0308
Gentisate aldehyde -0.164 -0.08 0.1419 -0.0263 0.0597 0.0591 -0.0129 0.0732 0 0.1361
Deoxyinosine 0.1393 -0.1476 0.0054 -0.2119 -0.2317 0.0448 0.1088 0.21 0 -0.1146
Campesterol 0.0553 -0.0638 0.0645 0.1166 0.2443 -0.3019 -0.0029 0.1417 0 -0.2761
Estrone glucuronide 0.102 5e-04 0.1053 0.1984 0.1704 0.0945 -0.2145 -0.0853 0 0.1071
Vitamin K1 epoxide 0.0576 0.0637 0.2454 0.2247 -0.2224 0.0776 -0.0405 0.2112 0 0.1349
D-Fructose -0.0272 -0.2162 0.0129 -0.1314 0.0326 -0.2446 -0.0517 -0.1052 0 -0.227
Chitin -0.0962 -0.1615 -0.1904 -0.1659 0.0523 -0.0089 0.0886 -0.0786 0 -0.222
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.1457 -0.1821 -0.0028 -0.3613 0.2339 -0.157 0.1531 -0.0887 0 -0.1901
N(pi)-Methyl-L-histidine -0.0633 0.043 0.1535 0.0801 -0.0143 0.0388 0.2157 -0.0753 0 0.039
Dihomo-gamma-linolenate 0.0696 -0.1546 -0.0261 -0.0491 0.0827 -0.0513 -0.08 -0.0753 0 -0.1434
Taurocholate 0.1986 0.1047 0.2533 0.1562 0.1635 -0.0904 -0.026 0.139 0 -0.0234
Deoxyuridine -0.1043 0.2223 0.1925 0.2665 -0.0068 -0.0106 0.0536 -0.0718 0 0.2452

P-values:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia
Sphingosine 1-phosphate 0.9417 0.7564 0.6804 0.6422 0.4699 0.0234 0.7913 0.867 1 0.177
Pantetheine 0.9558 0.8284 0.9558 0.9558 0.5573 0.4699 0.9558 0.7913 1 0.762
Inosine 0.9352 0.9679 0.9866 0.7913 0.5568 0.5171 0.7913 0.8506 1 0.9558
Sphingosine 0.987 0.9044 0.7564 0.8817 0.4699 0.4699 0.9558 0.8284 1 0.8365
4,6-Dihydroxyquinoline 0.7913 0.9866 0.4699 0.9866 0.4699 0.8896 0.7609 0.8385 1 0.8506
3beta-Hydroxypregn-5-en-20-one sulfate 0.5568 0.6293 0.9633 0.0678 0.0678 0.4699 0.8284 0.8284 1 0.4699
Prostaglandin G2 0.9198 0.9558 0.3805 0.5091 0.7564 0.4699 0.6151 0.8481 1 0.5152
L-Phenylalanine 0.7778 0.7609 0.7465 0.3805 0.9249 0.7997 0.9558 0.7778 1 0.8443
5-Hydroxykynurenamine 0.8284 0.7465 0.7913 0.0678 0.7913 0.7564 0.9558 0.7609 1 0.7913
Hippurate 0.6151 0.7564 0.5568 0.6002 0.7465 0.758 0.7465 0.8506 1 0.9558
Benzo[a]pyrene-7,8-diol 0.9558 0.7614 0.987 0.7349 0.5152 0.9558 0.7465 0.7465 1 0.758
16-Glucuronide-estriol 0.6151 0.839 0.8918 0.758 0.3805 0.8284 0.6355 0.7778 1 0.7322
S-Sulfanylglutathione 0.7564 0.7778 0.5568 0.0336 0.7913 0.9298 0.5568 0.7778 1 0.3805
Estradiol-17beta 3-glucuronide 0.9794 0.906 0.9198 0.9536 0.7778 0.9249 0.8284 0.7913 1 0.8284
L-Alanine 0.9632 0.7564 0.7913 0.6151 0.5072 0.5091 0.9249 0.7465 1 0.9632
L-Tryptophan 0.7564 0.7465 0.9866 0.7155 0.5152 0.8896 0.839 0.7465 1 0.7778
1,2-Dihydronaphthalene-1,2-diol 0.7913 0.8896 0.8284 0.9558 0.7913 0.9249 0.9558 0.8284 1 0.839
Deoxyribose 0.9203 0.8481 0.7913 0.7564 0.9558 0.7913 0.7778 0.7465 1 0.9558
Gentisate aldehyde 0.7465 0.8443 0.7564 0.9558 0.8896 0.8896 0.975 0.8506 1 0.758
Deoxyinosine 0.7564 0.7564 0.9866 0.5846 0.5568 0.9249 0.7913 0.5846 1 0.7913
Campesterol 0.9035 0.8817 0.8817 0.7913 0.5171 0.4699 0.987 0.7564 1 0.4699
Estrone glucuronide 0.7997 0.9973 0.7924 0.6151 0.7465 0.8284 0.5778 0.8385 1 0.7913
Vitamin K1 epoxide 0.8918 0.8817 0.5171 0.5568 0.5568 0.8481 0.9301 0.5846 1 0.758
D-Fructose 0.9558 0.5778 0.975 0.7609 0.9558 0.5171 0.906 0.7924 1 0.5568
Chitin 0.8284 0.7465 0.641 0.7465 0.906 0.9866 0.8284 0.8461 1 0.5568
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.7564 0.6853 0.987 0.2223 0.5568 0.7465 0.7503 0.8284 1 0.641
N(pi)-Methyl-L-histidine 0.8817 0.9249 0.7503 0.8443 0.9739 0.9336 0.5778 0.8481 1 0.9336
Dihomo-gamma-linolenate 0.8625 0.7503 0.9558 0.9174 0.839 0.906 0.8443 0.8481 1 0.7564
Taurocholate 0.6151 0.7924 0.5152 0.7465 0.7465 0.8284 0.9558 0.7564 1 0.9558
Deoxyuridine 0.7924 0.5568 0.6384 0.5072 0.9866 0.9813 0.906 0.8506 1 0.5171
Metabolic profile vs Differentially significant metabolites
Image 1

Correlation coefficients:

Body.Weight Subcutaneous.Fat Visceral.Fat Pancrease.Weight Insulin Blood.Glucose Real.HOMA.IR Serum.Acetate Serum.Butyrate Serum.Propionate Serum.Isovalerate Liver.Triglycerides
L-Lysine -0.1127 -0.4168 0.1775 -0.0844 0.0758 0.3488 0.2726 0.1645 0.007 0.1729 -0.1665 0.1668
L-Tyrosine -0.2259 -0.3724 0.2019 0.0189 -0.1104 0.2439 0.1273 0.2694 0.0705 0.0815 -0.0184 0.1467
L-Pipecolate 0.5064 0.3222 -0.0315 -0.2204 -0.0586 -0.24 -0.2462 -0.519 -0.1858 -0.021 -0.1921 -0.1871
3-Carbamoyl-2-phenylpropionic acid 0.0149 0.063 -0.0815 0.0628 -0.0938 -0.0841 -0.0586 -0.2114 -0.1164 -0.2129 -0.1573 -0.1324
all-trans-4-Hydroxyretinoic acid 0.2361 0.0462 0.2308 0.3092 0.2878 -0.0833 0.094 -0.1265 0.1571 0.0287 0.3049 -0.1214
Farnesylcysteine 0.1301 -0.0439 0.2351 0.1032 0.0091 0.0179 -0.0733 -0.0066 0.2036 0.0451 0.2219 -0.2258
15H-11,12-EETA 0.3624 0.1471 0.2659 0.0479 0.0593 -0.059 0.0062 -0.0832 -0.1516 0.0745 -0.0021 -0.109
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate -0.2377 -0.0456 0.1972 0.0017 0.3064 -0.0206 0.2233 0.0235 0.1602 0.1888 0.4823 0.0023
Leukotriene D4 0.4848 0.271 0.0248 0.0811 -0.1763 -0.0927 -0.1722 -0.1984 -0.1111 0.0547 -0.2853 -0.0908
Pantetheine 0.5814 0.3533 -0.0518 0.2391 0.0161 -0.1652 -0.1724 -0.6053 -0.0868 0.0575 0.0539 -0.2374
17alpha,21-Dihydroxypregnenolone 0.5306 0.387 -0.0588 0.157 -0.1086 -0.1545 -0.238 -0.4237 0.0108 0.0972 0.0028 -0.2132
Ophthalmate 0.0893 0.1785 -0.0688 0.063 -0.0303 -0.1774 -0.1174 -0.3124 -0.0505 -0.2025 0.2736 -0.1038
Tetrahydrocorticosterone -0.0504 0.1682 -0.1973 -0.0555 -0.0879 -0.2103 -0.1363 -0.0935 -0.107 -0.325 0.0808 -0.2454
6-Thioinosine-5'-monophosphate 0.0307 -0.0907 0.171 0.0219 -0.0114 0.1387 0.1643 0.2172 0.0689 -0.0037 -0.0072 0.174
Pantetheine 4'-phosphate -0.0863 0.1314 -0.0961 0.1379 0.1398 -0.2197 0.0255 -0.0566 0.1046 -0.0107 0.3027 -0.0657
L-Phenylalanine 0.0603 -0.073 -0.0469 -0.0961 -0.2415 0.0556 -0.0451 -0.0039 -0.2277 -0.1958 -0.4271 0.1567
Glutathione episulfonium ion -0.0201 -0.0422 0.1473 0.0674 -0.0596 0.146 0.0591 0.0044 0.1123 0.011 -0.0553 0.2271
Chitin -0.2496 -0.1547 -0.0152 -0.1761 -0.0054 -0.0747 -0.0411 0.0773 0.0305 -0.216 -0.0841 0.1601
L-Isoleucine -0.3721 -0.1061 -0.1069 -0.0495 0.1241 -0.0881 -0.0277 0.3181 0.2025 0.0993 0.1932 -0.1283
9-Hydroxybenzo[a]pyrene-4,5-oxide 0.0744 -0.0207 0.0791 -0.0821 -0.0094 -0.0729 -0.065 0.1232 0.104 0.1615 0.1602 -0.3558
5-Phenyl-1,3-oxazinane-2,4-dione -0.04 0.0016 -0.1193 0.0988 -0.1101 -0.0465 -0.0806 0.2027 -0.3423 -0.1991 -0.3259 0.063
Biotin -0.3185 -0.2389 -0.0683 -0.1304 -0.0576 -0.0828 -0.0998 0.2088 -0.0065 -0.1218 0.1219 -0.1075
L-Proline 0.0604 0.0587 0.1999 -0.0467 0.3673 -0.0013 0.1787 -0.0616 0.0757 0.0948 0.3015 0.0076
trans-2-Enoyl-OPC4-CoA -0.4201 -0.2929 0.0117 -0.0845 0.2126 0.1549 0.2433 0.2452 0.1871 -0.0168 0.3512 -0.0201
Testosterone glucuronide 0.0691 -0.0524 -0.0597 -0.1724 0.0245 0.0554 0.0289 0.0063 -0.1281 0.0199 -0.0927 0.0395
Nicotinate D-ribonucleoside -0.0705 -0.1912 0.0338 -0.0982 -0.1518 0.1306 -0.0214 0.2659 -0.1299 0.0445 -0.3015 0.2656
Dextrin -0.0595 -0.0417 0.1688 -0.0531 -0.0665 -0.1395 -0.1286 0.1226 0.0685 -0.1755 0.1763 -0.0365
N-Formimino-L-glutamate -0.1672 -0.0065 -0.1327 -0.1776 -0.003 -0.299 -0.1994 -0.0218 0.1648 -0.2027 0.0528 -0.1125
2,3-Epoxymenaquinone 0.0153 -0.2723 0.0393 0.0342 -0.0347 0.0924 0.0103 0.2025 -0.0932 -0.0206 0.0085 0.0723
Sucrose 0.3752 0.0649 -0.0364 -0.0118 -0.0022 -0.0643 -0.0254 -0.2637 -0.1456 0.044 -0.1345 0.04

P-values:

Body.Weight Subcutaneous.Fat Visceral.Fat Pancrease.Weight Insulin Blood.Glucose Real.HOMA.IR Serum.Acetate Serum.Butyrate Serum.Propionate Serum.Isovalerate Liver.Triglycerides
L-Lysine 0.8225 0.0302 0.5938 0.884 0.9058 0.1081 0.3101 0.6084 0.9923 0.595 0.6084 0.6084
L-Tyrosine 0.445 0.082 0.5099 0.9878 0.8274 0.4069 0.7523 0.3132 0.9058 0.884 0.988 0.6771
L-Pipecolate 0.0026 0.1736 0.9691 0.4648 0.9058 0.4069 0.4069 0.0019 0.5591 0.984 0.5362 0.5542
3-Carbamoyl-2-phenylpropionic acid 0.9923 0.9058 0.884 0.9058 0.869 0.884 0.9058 0.4906 0.8008 0.4873 0.632 0.7491
all-trans-4-Hydroxyretinoic acid 0.409 0.9242 0.4342 0.2012 0.2508 0.884 0.869 0.7546 0.632 0.9735 0.2038 0.7706
Farnesylcysteine 0.7491 0.9242 0.4097 0.8415 0.9923 0.9883 0.9058 0.9923 0.5099 0.9242 0.461 0.445
15H-11,12-EETA 0.0939 0.6771 0.315 0.9242 0.9058 0.9058 0.9923 0.884 0.6508 0.9058 0.9923 0.8315
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate 0.4069 0.9242 0.5129 0.9923 0.2038 0.984 0.4572 0.984 0.6238 0.551 0.0049 0.9923
Leukotriene D4 0.0049 0.3103 0.984 0.884 0.5938 0.869 0.595 0.5129 0.8274 0.9071 0.257 0.8744
Pantetheine 2e-04 0.1066 0.9122 0.4069 0.9923 0.6084 0.595 1e-04 0.884 0.9063 0.9101 0.4069
17alpha,21-Dihydroxypregnenolone 0.0016 0.0675 0.9058 0.632 0.8315 0.6365 0.4069 0.0297 0.9923 0.869 0.9923 0.4873
Ophthalmate 0.8822 0.5938 0.9058 0.9058 0.9691 0.5938 0.7961 0.194 0.9156 0.5099 0.3101 0.8411
Tetrahydrocorticosterone 0.9156 0.6084 0.5129 0.9063 0.884 0.4926 0.7322 0.869 0.8321 0.1695 0.884 0.4069
6-Thioinosine-5'-monophosphate 0.9691 0.8744 0.5995 0.984 0.9923 0.7216 0.6084 0.4776 0.9058 0.9923 0.9923 0.595
Pantetheine 4'-phosphate 0.884 0.7491 0.869 0.7237 0.7193 0.4648 0.984 0.9063 0.8411 0.9923 0.2038 0.9058
L-Phenylalanine 0.9058 0.9058 0.9242 0.869 0.4069 0.9063 0.9242 0.9923 0.445 0.5178 0.0297 0.632
Glutathione episulfonium ion 0.984 0.9331 0.6771 0.9058 0.9058 0.6771 0.9058 0.9923 0.8225 0.9923 0.9063 0.445
Chitin 0.4069 0.6365 0.9923 0.5938 0.9923 0.9058 0.9342 0.9035 0.9691 0.4801 0.884 0.6238
L-Isoleucine 0.082 0.8345 0.8321 0.9191 0.7706 0.884 0.9774 0.1766 0.5099 0.8665 0.5326 0.7501
9-Hydroxybenzo[a]pyrene-4,5-oxide 0.9058 0.984 0.8927 0.884 0.9923 0.9058 0.9058 0.7706 0.8411 0.6238 0.6238 0.1054
5-Phenyl-1,3-oxazinane-2,4-dione 0.9342 0.9923 0.7846 0.8665 0.8274 0.9242 0.884 0.5099 0.1216 0.5129 0.1695 0.9058
Biotin 0.1766 0.4069 0.9058 0.7491 0.9063 0.884 0.8665 0.4984 0.9923 0.7706 0.7706 0.8321
L-Proline 0.9058 0.9058 0.5129 0.9242 0.0874 0.9923 0.5938 0.9058 0.9058 0.869 0.2038 0.9923
trans-2-Enoyl-OPC4-CoA 0.0299 0.2312 0.9923 0.884 0.4873 0.6365 0.4069 0.4069 0.5542 0.9923 0.1068 0.984
Testosterone glucuronide 0.9058 0.9109 0.9058 0.595 0.984 0.9063 0.9735 0.9923 0.7501 0.984 0.869 0.9342
Nicotinate D-ribonucleoside 0.9058 0.5373 0.957 0.8674 0.6508 0.7491 0.984 0.315 0.7491 0.9242 0.2038 0.315
Dextrin 0.9058 0.9333 0.6084 0.9109 0.9058 0.7193 0.7501 0.7706 0.9058 0.5938 0.5938 0.9484
N-Formimino-L-glutamate 0.6084 0.9923 0.7491 0.5938 0.9923 0.209 0.5129 0.984 0.6084 0.5099 0.9109 0.8225
2,3-Epoxymenaquinone 0.9923 0.3101 0.9342 0.957 0.957 0.869 0.9923 0.5099 0.869 0.984 0.9923 0.9058
Sucrose 0.082 0.9058 0.9484 0.9923 0.9923 0.9058 0.984 0.3198 0.6771 0.9242 0.7435 0.9342
Differentially significant microbes vs Differentially significant metabolites
Image 1

Correlation coefficients:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia
L-Lysine -0.0234 -0.0251 0.561 -0.1117 -0.2891 -0.1895 0.2351 -0.1403 0 -0.2741
L-Tyrosine -0.0504 -0.1012 0.362 0.0669 -0.0242 -0.1253 0.2177 -0.0141 0 -0.0929
L-Pipecolate 0.1523 0.1374 0.079 0.0386 -0.196 -0.0515 -0.0342 -0.2178 0 -0.0729
3-Carbamoyl-2-phenylpropionic acid -0.0464 -0.0967 -0.3313 0.0527 -0.1867 0.3021 0.0638 -0.1039 0 0.2474
all-trans-4-Hydroxyretinoic acid -0.0083 0.1145 0.0834 0.4201 0.3001 -0.0783 -0.2528 0.188 0 0.181
Farnesylcysteine -0.176 -0.0967 0.1805 0.2427 -0.0357 0.0113 -0.17 0.0774 0 0.0045
15H-11,12-EETA 0.1737 -0.1012 0.0455 0.3567 -0.0568 -0.0363 0.0552 -0.1257 0 0.124
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate -0.0863 0.0793 -0.2478 0.091 0.3707 -0.0304 -0.2285 0.3059 0 0.0414
Leukotriene D4 0.1225 0.0606 0.0144 -0.0638 -0.0323 -0.1779 0.0782 -0.0713 0 -0.0429
Pantetheine 0.102 0.1703 0.1079 0.0531 -0.0246 0.1045 -0.4003 -0.1458 0 0.0932
17alpha,21-Dihydroxypregnenolone 0.1091 0.1786 0.0179 0.1958 0.0401 0.1107 -0.3958 -0.0626 0 0.1439
Ophthalmate -0.0073 0.143 -0.3225 0.0083 0.3038 -0.0218 -0.3553 0.1704 0 0.0683
Tetrahydrocorticosterone -0.0517 -0.0967 -0.3648 -0.0477 0.0234 0.3255 -0.082 -0.0149 0 0.2474
6-Thioinosine-5'-monophosphate 0.0309 -0.1146 -0.0345 0.25 0.0596 -0.0299 0.1466 -0.0681 0 0.0493
Pantetheine 4'-phosphate -0.1802 0.0576 -0.2556 0.0519 0.2498 0.121 -0.0664 0.0788 0 0.2378
L-Phenylalanine 0.2233 -0.1365 -0.1028 -0.2666 -0.0776 0.121 0.1083 -0.0213 0 -0.0084
Glutathione episulfonium ion 0.0501 0.074 0.2329 0.1442 -0.0913 -0.0701 0.0081 -0.0201 0 -0.0801
Chitin 0.0116 -0.0967 -0.1365 -0.1888 -0.0856 0.0945 0.1656 0.0149 0 -0.0743
L-Isoleucine -0.2078 0.0936 -0.1358 0.0416 0.0704 0.0105 7e-04 0.0661 0 -0.1319
9-Hydroxybenzo[a]pyrene-4,5-oxide -0.1562 0.0922 0.1452 0.2001 0.1208 -0.1168 -0.1651 0.1246 0 -0.0755
5-Phenyl-1,3-oxazinane-2,4-dione -0.0032 -0.1234 0.0454 -0.241 -0.1132 -0.2164 0.2188 0.012 0 -0.068
Biotin -0.0625 0.0573 0.0011 0.0196 0.1459 -0.1628 -0.1479 0.1854 0 0.0327
L-Proline -0.0655 -0.1278 0.0043 0.0848 0.1636 0.1488 0.0929 0.0553 0 0.0556
trans-2-Enoyl-OPC4-CoA -0.095 0.1878 -0.1328 0.0941 0.2852 -0.1183 -0.1892 0.2861 0 -0.0737
Testosterone glucuronide -0.1278 0.0793 0.3077 -0.1022 -0.168 -0.0923 0.1188 -0.1523 0 -0.2789
Nicotinate D-ribonucleoside -0.0211 -0.1102 -0.0674 0.0264 -0.0293 0.0331 0.0607 0.0279 0 0.2178
Dextrin -0.0556 0.0145 -0.2151 0.2945 0.0413 0.1512 -0.1536 0.0744 0 0.0695
N-Formimino-L-glutamate 0.0167 0.1548 -0.2301 -0.0978 0.044 0.0643 -0.2274 0.1243 0 -0.0121
2,3-Epoxymenaquinone 0.0737 -0.0084 0.2339 0.0103 -0.2651 -0.141 0.0628 -0.1587 0 -0.2092
Sucrose 0.0604 -0.0884 0.2614 -0.3713 0.1313 -0.1313 -0.094 0.0609 0 -0.0758

P-values:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia
L-Lysine 0.9625 0.9625 8e-04 0.8749 0.3334 0.6779 0.4946 0.8097 1 0.3832
L-Tyrosine 0.9007 0.8749 0.144 0.8904 0.9625 0.8401 0.5325 0.9724 1 0.8749
L-Pipecolate 0.7986 0.8207 0.8904 0.932 0.6567 0.899 0.9463 0.5325 1 0.8904
3-Carbamoyl-2-phenylpropionic acid 0.9132 0.8749 0.2384 0.899 0.6779 0.2977 0.8904 0.8749 1 0.4505
all-trans-4-Hydroxyretinoic acid 0.9724 0.8636 0.8904 0.1123 0.2977 0.8904 0.4505 0.6779 1 0.6986
Farnesylcysteine 0.7092 0.8749 0.6986 0.4757 0.9436 0.9724 0.7276 0.8904 1 0.9848
15H-11,12-EETA 0.7213 0.8749 0.9132 0.144 0.8939 0.9436 0.8939 0.8401 1 0.8401
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate 0.8904 0.8904 0.4505 0.8749 0.144 0.9508 0.5062 0.2977 1 0.9212
Leukotriene D4 0.8401 0.8904 0.9724 0.8904 0.9468 0.7009 0.8904 0.8904 1 0.9212
Pantetheine 0.8749 0.7276 0.8749 0.899 0.9625 0.8749 0.118 0.7999 1 0.8749
17alpha,21-Dihydroxypregnenolone 0.8749 0.7009 0.9724 0.6567 0.9253 0.8749 0.118 0.8904 1 0.7999
Ophthalmate 0.9736 0.8005 0.2484 0.9724 0.2977 0.9658 0.144 0.7276 1 0.8904
Tetrahydrocorticosterone 0.899 0.8749 0.144 0.9093 0.9625 0.2484 0.8904 0.9724 1 0.4505
6-Thioinosine-5'-monophosphate 0.9508 0.8636 0.9463 0.4505 0.8919 0.9508 0.7999 0.8904 1 0.9023
Pantetheine 4'-phosphate 0.6986 0.8939 0.4505 0.899 0.4505 0.8401 0.8904 0.8904 1 0.4909
L-Phenylalanine 0.5296 0.8207 0.8749 0.422 0.8904 0.8401 0.8749 0.9658 1 0.9724
Glutathione episulfonium ion 0.9007 0.8904 0.4946 0.7999 0.8749 0.8904 0.9724 0.9678 1 0.8904
Chitin 0.9724 0.8749 0.8207 0.6779 0.8904 0.8749 0.7466 0.9724 1 0.8904
L-Isoleucine 0.5769 0.8749 0.8207 0.9212 0.8904 0.9724 0.9957 0.8904 1 0.832
9-Hydroxybenzo[a]pyrene-4,5-oxide 0.7971 0.8749 0.7999 0.6383 0.8401 0.8562 0.7466 0.8401 1 0.8904
5-Phenyl-1,3-oxazinane-2,4-dione 0.9877 0.8401 0.9132 0.4773 0.8684 0.533 0.5325 0.9724 1 0.8904
Biotin 0.8904 0.8939 0.9957 0.9678 0.7999 0.7506 0.7999 0.6797 1 0.9468
L-Proline 0.8904 0.8401 0.9848 0.8904 0.7506 0.7999 0.8749 0.8939 1 0.8939
trans-2-Enoyl-OPC4-CoA 0.8749 0.6779 0.832 0.8749 0.3334 0.8489 0.6779 0.3334 1 0.8904
Testosterone glucuronide 0.8401 0.8904 0.2977 0.8749 0.7373 0.8749 0.8489 0.7986 1 0.3633
Nicotinate D-ribonucleoside 0.9658 0.8749 0.8904 0.9622 0.951 0.9468 0.8904 0.9566 1 0.5325
Dextrin 0.8939 0.9724 0.534 0.3181 0.9212 0.7999 0.7986 0.8904 1 0.8904
N-Formimino-L-glutamate 0.9724 0.7986 0.5062 0.8749 0.9188 0.8904 0.5062 0.8401 1 0.9724
2,3-Epoxymenaquinone 0.8904 0.9724 0.4946 0.9724 0.422 0.8097 0.8904 0.7817 1 0.575
Sucrose 0.8904 0.8904 0.4362 0.144 0.832 0.832 0.8749 0.8904 1 0.8904
Metabolic profile vs Differentially significant metabolites
Image 1

Correlation coefficients:

Body.Weight Subcutaneous.Fat Visceral.Fat Pancrease.Weight Insulin Blood.Glucose Real.HOMA.IR Serum.Acetate Serum.Butyrate Serum.Propionate Serum.Isovalerate Liver.Triglycerides
N6,N6,N6-Trimethyl-L-lysine -0.7976 -0.4756 0.1283 0.0683 -0.1644 0.0387 -0.1052 -0.3739 -0.0063 0.056 0.1911 0.2148
L-2-Aminoadipate -0.7215 -0.4534 0.15 -0.0423 -0.2544 0.1304 -0.1064 -0.2753 0.0772 -0.0097 0.2901 0.1845
L-Leucine -0.534 -0.4448 0.3383 0.0292 -0.2182 0.2393 -0.0157 -0.1607 0.0032 0.0617 0.1755 0.1971
L-Valine -0.4621 -0.3116 0.243 -0.1843 -0.2109 0.0622 -0.1046 -0.138 0.0973 0.1284 -0.0092 0.1199
5-Hydroxyindoleacetate -0.6365 -0.4439 -0.0518 0.2348 -0.1565 -0.0695 -0.0321 -0.3675 0.0191 -0.0937 0.3564 0.1909
L-Arginine -0.4812 -0.3115 0.1734 0.2354 -0.2989 6e-04 -0.2283 -0.2512 -0.155 -0.0825 0.1466 0.3569
L-Methionine -0.6953 -0.4259 0.1339 -0.0523 -0.1117 0.1133 -0.0762 -0.2042 -0.0163 0.0158 0.1345 -0.0766
L-2-Amino-3-oxobutanoic acid 0.2533 0.0311 0.3093 -0.4064 0.0762 0.4134 0.3096 0.1023 -0.0619 -0.0169 -0.4483 0.0103
N-Carbamoyl-L-aspartate -0.267 0.062 -0.1719 0.3605 -0.0011 -0.2667 -0.1459 -0.2468 -0.0671 0.2426 0.0606 -0.0018
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.478 0.1511 0.0262 -0.2243 0.1663 0.1027 0.1603 0.1506 0.1527 -0.0928 -0.085 0.0936
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate -0.1302 -0.2924 0.3963 -0.458 -0.2339 0.2864 0.004 0.0894 -0.064 -0.0327 -0.0963 0.1296
L-2-Aminoadipate 6-semialdehyde -0.3836 -0.2855 0.1449 -0.0704 -0.2164 0.0238 -0.073 -0.0726 0.2031 -0.0607 0.1973 0.1954
1,2-Dihydronaphthalene-1,2-diol -0.5283 -0.1434 0.3863 0.1059 -0.1233 0.1139 -0.065 -0.1912 0.1239 0.1932 0.1421 0.2678
trans-2-Enoyl-OPC4-CoA -0.0349 0.0893 -0.1332 0.2981 0.1261 -0.2003 0.0059 -0.2828 0.0697 -0.0641 0.1462 -0.087
5,6-DHET 0.0472 0.0013 0.0167 -0.0607 0.0347 0.1659 0.1407 0.0098 -0.0516 0.2847 -0.2459 -0.1371
3-Hydroxypropanoate -0.5764 -0.4091 0.0855 -0.0689 -0.0661 0.0149 -0.0723 -0.2491 0.0133 0.1384 0.1539 0.1194
L-Noradrenaline -0.2104 -0.0228 0.0297 0.2223 -0.1653 0.0736 -0.0554 -0.1059 0.1416 0.1728 0.2397 0.0893
3,7-Dimethyluric acid -0.1985 -0.1603 0.1123 -0.1927 -0.1652 0.3025 0.1385 0.1138 -0.1207 -0.0496 -0.2758 0.2654
N-Acetyl-D-glucosamine -0.5737 -0.3514 0.1152 -0.0208 0.059 -0.1922 -0.034 -0.2559 0.0047 0.068 0.1047 0.0637
Androstenediol -0.0604 -0.0088 -0.2516 0.1333 0.1479 -0.2774 -0.0118 0.2782 -0.0381 0.1385 -0.0042 -0.1174
2-Methoxyestrone 3-glucuronide -0.0954 -0.0485 -0.312 0.3084 -0.0599 -0.3123 -0.3008 -0.0829 0.0334 0.0064 0.2688 0.1285
Eicosanoyl-CoA 0.139 0.0438 -0.047 0.2558 -0.0137 -0.1397 -0.0482 -0.1372 -0.0403 -0.1828 0.2039 -0.0233
Estradiol-17beta 3-glucuronide 0.3324 0.3304 -0.0463 0.0312 0.0435 -0.1852 -0.0319 -0.0439 -0.0077 0.2023 -0.0443 -0.093
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone -0.35 -0.1518 -0.1649 0.237 0.0046 -0.1824 -0.1477 -0.0853 2e-04 0.0401 0.325 -0.0755
Retinol -0.3008 -0.2553 0.1748 -0.3189 -0.1676 0.0461 -0.127 -0.0478 -0.0045 0.1075 -0.0267 -0.0799
4,6-Dihydroxyquinoline 0.1366 0.0309 0.3464 -0.0742 0.1293 0.0485 0.0659 -7e-04 0.1009 -0.0328 -0.1541 0.028
Cadaverine 0.0051 0.1239 -0.1008 0.0274 -0.0111 -0.0882 -0.0949 -0.0721 -0.0097 0.1668 -0.1999 -0.0374
Deoxyribose 0.4492 0.0854 -0.0728 -0.1383 0.058 0.0651 0.0398 0.0055 -0.1318 -0.0726 0.0088 0.0751
L-Cysteate -0.4868 -0.3652 -0.0933 0.0209 -0.0244 0.1144 0.1194 -0.228 0.0155 -0.1192 0.1775 0.1997
Chitin 0.505 -0.0055 0.1083 -0.1538 -0.0121 0.075 0.1142 0.2888 -0.0236 -0.3478 6e-04 -0.0621

P-values:

Body.Weight Subcutaneous.Fat Visceral.Fat Pancrease.Weight Insulin Blood.Glucose Real.HOMA.IR Serum.Acetate Serum.Butyrate Serum.Propionate Serum.Isovalerate Liver.Triglycerides
N6,N6,N6-Trimethyl-L-lysine 0 0.0059 0.6999 0.8841 0.6115 0.9516 0.7776 0.0583 0.999 0.9028 0.5009 0.4237
L-2-Aminoadipate 0 0.0101 0.6651 0.9395 0.2846 0.6999 0.7776 0.2216 0.8777 0.999 0.1934 0.5349
L-Leucine 0.0012 0.011 0.102 0.9676 0.4112 0.3244 0.999 0.6296 0.999 0.8841 0.5825 0.4895
L-Valine 0.0087 0.1523 0.3145 0.5349 0.444 0.8841 0.7776 0.6837 0.8151 0.6999 0.999 0.7308
5-Hydroxyindoleacetate 0 0.011 0.9201 0.3376 0.6557 0.8841 0.9629 0.0663 0.9966 0.8199 0.0765 0.5009
L-Arginine 0.0057 0.1523 0.5886 0.3376 0.1709 0.999 0.3639 0.2889 0.6579 0.8574 0.6751 0.0765
L-Methionine 0 0.0183 0.6942 0.9201 0.7539 0.7489 0.8777 0.4794 0.999 0.999 0.6942 0.8777
L-2-Amino-3-oxobutanoic acid 0.2864 0.9629 0.1524 0.0283 0.8777 0.0252 0.1524 0.7882 0.8841 0.999 0.0106 0.999
N-Carbamoyl-L-aspartate 0.2448 0.8841 0.5909 0.0736 0.999 0.2448 0.6751 0.3038 0.8841 0.3145 0.8841 0.999
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.0058 0.6651 0.9756 0.3819 0.6115 0.7882 0.6296 0.6651 0.6624 0.8199 0.8461 0.8199
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate 0.6999 0.1881 0.0359 0.0093 0.3383 0.2008 0.999 0.8352 0.8841 0.9629 0.8193 0.6999
L-2-Aminoadipate 6-semialdehyde 0.0469 0.2008 0.6792 0.8841 0.4179 0.982 0.8777 0.8777 0.4799 0.8841 0.4895 0.4964
1,2-Dihydronaphthalene-1,2-diol 0.0013 0.6837 0.0454 0.7776 0.7189 0.7489 0.8841 0.5009 0.7183 0.5009 0.6837 0.2448
trans-2-Enoyl-OPC4-CoA 0.9629 0.8352 0.6942 0.1709 0.7084 0.4845 0.999 0.2048 0.8841 0.8841 0.6751 0.8456
5,6-DHET 0.9294 0.999 0.999 0.8841 0.9629 0.6115 0.6837 0.999 0.9201 0.2008 0.305 0.6837
3-Hydroxypropanoate 2e-04 0.0273 0.8461 0.8841 0.8841 0.999 0.8777 0.2958 0.999 0.6837 0.6579 0.7308
L-Noradrenaline 0.444 0.982 0.9676 0.3895 0.6115 0.8777 0.9035 0.7776 0.6837 0.5887 0.3244 0.8352
3,7-Dimethyluric acid 0.4886 0.6296 0.7531 0.5009 0.6115 0.1682 0.6837 0.7489 0.7308 0.9294 0.2216 0.2474
N-Acetyl-D-glucosamine 2e-04 0.0837 0.7489 0.9887 0.8877 0.5009 0.9629 0.2837 0.999 0.8841 0.7776 0.8841
Androstenediol 0.8841 0.999 0.2889 0.6942 0.6743 0.2199 0.999 0.2199 0.9521 0.6837 0.999 0.7408
2-Methoxyestrone 3-glucuronide 0.8199 0.9294 0.1523 0.1524 0.8844 0.1523 0.1682 0.8574 0.9629 0.999 0.2448 0.6999
Eicosanoyl-CoA 0.6837 0.9345 0.9294 0.2837 0.999 0.6837 0.9294 0.6837 0.9473 0.5396 0.4794 0.982
Estradiol-17beta 3-glucuronide 0.1137 0.116 0.9294 0.9629 0.9345 0.5349 0.9629 0.9345 0.999 0.4806 0.9345 0.8199
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone 0.0843 0.6649 0.6115 0.3332 0.999 0.5396 0.6743 0.8461 0.999 0.9473 0.1276 0.8777
Retinol 0.1682 0.2837 0.5832 0.1424 0.6115 0.9294 0.7056 0.9294 0.999 0.7776 0.9749 0.8738
4,6-Dihydroxyquinoline 0.6837 0.9629 0.0867 0.8777 0.6999 0.9294 0.8841 0.999 0.792 0.9629 0.6579 0.9726
Cadaverine 0.999 0.7183 0.792 0.9736 0.999 0.8397 0.8199 0.8777 0.999 0.6115 0.4845 0.9542
Deoxyribose 0.0106 0.8461 0.8777 0.6837 0.8912 0.8841 0.9473 0.999 0.6999 0.8777 0.999 0.8777
L-Cysteate 0.0051 0.0679 0.8199 0.9887 0.982 0.7489 0.7308 0.3639 0.999 0.7308 0.5718 0.4845
Chitin 0.0029 0.999 0.7765 0.6579 0.999 0.8777 0.7489 0.1948 0.982 0.0863 0.999 0.8841
Differentially significant microbes vs Differentially significant metabolites
Image 1

Correlation coefficients:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia
N6,N6,N6-Trimethyl-L-lysine -0.4344 0.0218 0 -0.2056 0.2148 -0.283 0.3133 0.2451 -0.1377 -0.2701
L-2-Aminoadipate -0.429 0.0368 0 -0.1427 0.1587 -0.1553 0.2213 0.2194 -0.1868 -0.2195
L-Leucine -0.2424 0.0392 0 -0.1593 0.1132 -0.1948 0.3192 0.2131 -0.0804 -0.206
L-Valine -0.1138 0.0548 0 0.0346 -0.1157 -0.2269 0.2144 0.0495 0.0197 -0.0091
5-Hydroxyindoleacetate -0.4456 -0.0106 0 -0.1364 0.1982 -0.2066 0.4363 0.2977 -0.135 -0.2065
L-Arginine -0.2148 0.0455 0 -0.0955 0.2492 -0.149 0.2113 0.3281 -0.1196 -0.2407
L-Methionine -0.3293 0.1339 0 -0.174 0.144 -0.1835 0.1629 0.1296 -0.1097 -0.2095
L-2-Amino-3-oxobutanoic acid 0.4054 0.0432 0 0.0879 -0.4047 0.0108 -0.2254 -0.3038 -0.0874 0.1076
N-Carbamoyl-L-aspartate -0.2613 -0.0453 0 -0.0445 0.0556 0.021 0.2136 0.2737 0.2201 0.091
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.2156 0.0685 0 0.0954 -0.141 0.1545 -0.0778 -0.2395 -0.0948 0.0976
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate 0.0415 0.1883 0 -0.069 0.0181 0.0659 0.1425 -0.102 -0.0736 -0.0159
L-2-Aminoadipate 6-semialdehyde -0.3169 0.0812 0 -0.0834 -0.1223 -0.0429 0.2026 -0.1782 -0.3014 -0.1738
1,2-Dihydronaphthalene-1,2-diol -0.173 -0.1046 0 -0.1144 0.0573 -0.0444 0.1182 0.1165 -0.018 -0.0957
trans-2-Enoyl-OPC4-CoA -0.4092 -0.1433 0 -0.1668 0.1634 0.0847 0.0349 0.0282 0.0346 0.0428
5,6-DHET 0.2501 0.0794 0 -0.0794 -0.1956 0.0829 0.0761 -0.0323 -0.0261 0.2033
3-Hydroxypropanoate -0.2946 0.0851 0 -0.2214 0.245 -0.203 0.2874 0.1874 -0.13 -0.1198
L-Noradrenaline 0.1968 -0.0463 0 0.0748 0.0465 0.0327 0.3102 0.0804 0.0906 0.0112
3,7-Dimethyluric acid 0.0935 0.2801 0 0.0153 0.0219 0.1159 -0.0334 -0.0274 -0.249 0.0074
N-Acetyl-D-glucosamine -0.3615 0.0647 0 -0.0376 -0.0089 -0.4145 0.2037 0.0165 -0.2185 -0.3468
Androstenediol 0.0297 0.2704 0 0.1426 -0.0255 0.0167 0.0374 0.0265 0.1535 0.0657
2-Methoxyestrone 3-glucuronide -0.0953 -0.1243 0 0.0622 0.2547 -0.0422 0.2386 0.3661 0.0513 -0.1495
Eicosanoyl-CoA 0.1524 0.0617 0 -0.0533 0.1665 -0.2276 -0.1036 0.1249 -0.0906 -0.1365
Estradiol-17beta 3-glucuronide 0.2126 -0.1046 0 0.2325 -0.153 -0.0222 -0.1676 -0.1046 0.0623 0.1677
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone -0.0867 0.0611 0 -0.1223 0.4202 -0.2105 0.1095 0.2315 -0.0598 -0.1175
Retinol 0.1201 0.0948 0 0.0237 -0.0199 -0.0406 -0.0831 -0.0201 -0.1374 0.0398
4,6-Dihydroxyquinoline 0.2376 -0.1882 0 0.1584 -0.1883 0.0491 -0.1695 -0.1882 -0.0217 0.1998
Cadaverine -0.0106 -0.1503 0 0.035 -0.1025 0.0411 -0.0837 0.0615 0.0906 0.1454
Deoxyribose 0.0774 0.1334 0 0.0808 0.1821 0.0289 -0.0839 0.0617 -0.0179 0.0972
L-Cysteate -0.2825 -0.1057 0 0.0287 0.1861 -0.2508 0.1576 0.1187 -0.2235 -0.2934
Chitin 0.3629 -0.0313 0 -0.174 -0.2262 0.2274 -0.1453 -0.1782 -0.0077 0.1924

P-values:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia
N6,N6,N6-Trimethyl-L-lysine 0.0594 0.9372 1 0.4769 0.4769 0.3489 0.2809 0.4757 0.6666 0.3843
L-2-Aminoadipate 0.0594 0.9234 1 0.6472 0.6147 0.6268 0.4769 0.4769 0.5144 0.4769
L-Leucine 0.4769 0.921 1 0.6147 0.7363 0.5009 0.2751 0.4769 0.8054 0.4769
L-Valine 0.7361 0.8934 1 0.9234 0.7319 0.4769 0.4769 0.9164 0.9372 0.9552
5-Hydroxyindoleacetate 0.0594 0.9521 1 0.6666 0.4951 0.4769 0.0594 0.3172 0.6723 0.4769
L-Arginine 0.4769 0.9197 1 0.7877 0.4686 0.6359 0.4769 0.2442 0.7319 0.4769
L-Methionine 0.2442 0.6738 1 0.5627 0.6472 0.5278 0.598 0.6927 0.7544 0.4769
L-2-Amino-3-oxobutanoic acid 0.0594 0.9197 1 0.8054 0.0594 0.9521 0.4769 0.3083 0.8054 0.7638
N-Carbamoyl-L-aspartate 0.4368 0.9197 1 0.9197 0.8919 0.9372 0.4769 0.3839 0.4769 0.7957
3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane 0.4769 0.8532 1 0.7877 0.6534 0.6268 0.8109 0.4769 0.7877 0.7877
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate 0.9197 0.5144 1 0.8532 0.9372 0.8642 0.6472 0.7717 0.8252 0.9384
L-2-Aminoadipate 6-semialdehyde 0.2751 0.8054 1 0.8054 0.728 0.9197 0.4769 0.5486 0.3087 0.5627
1,2-Dihydronaphthalene-1,2-diol 0.5627 0.7667 1 0.7361 0.8847 0.9197 0.7319 0.7319 0.9372 0.7877
trans-2-Enoyl-OPC4-CoA 0.0594 0.6472 1 0.5827 0.598 0.8054 0.9234 0.9331 0.9234 0.9197
5,6-DHET 0.4686 0.8054 1 0.8054 0.5009 0.8054 0.8161 0.9263 0.9349 0.4769
3-Hydroxypropanoate 0.3174 0.8054 1 0.4769 0.4757 0.4769 0.3428 0.5144 0.6927 0.7319
L-Noradrenaline 0.499 0.9197 1 0.8207 0.9197 0.9263 0.2839 0.8054 0.7957 0.9521
3,7-Dimethyluric acid 0.7924 0.3522 1 0.9384 0.9372 0.7319 0.9263 0.9348 0.4686 0.9568
N-Acetyl-D-glucosamine 0.1393 0.8664 1 0.9234 0.9552 0.0594 0.4769 0.9384 0.4769 0.1832
Androstenediol 0.9331 0.3843 1 0.6472 0.9349 0.9384 0.9234 0.9349 0.6268 0.8642
2-Methoxyestrone 3-glucuronide 0.7877 0.7225 1 0.8664 0.4686 0.9197 0.4769 0.1393 0.9091 0.6359
Eicosanoyl-CoA 0.6268 0.8664 1 0.9 0.5827 0.4769 0.7697 0.7225 0.7957 0.6666
Estradiol-17beta 3-glucuronide 0.4769 0.7667 1 0.4769 0.6268 0.9372 0.5827 0.7667 0.8664 0.5827
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone 0.8054 0.8664 1 0.728 0.0594 0.4769 0.7544 0.4769 0.8711 0.7319
Retinol 0.7319 0.7877 1 0.9372 0.9372 0.9197 0.8054 0.9372 0.6666 0.921
4,6-Dihydroxyquinoline 0.4769 0.5144 1 0.6147 0.5144 0.9164 0.5827 0.5144 0.9372 0.4907
Cadaverine 0.9521 0.6359 1 0.9234 0.7717 0.9197 0.8054 0.8664 0.7957 0.6472
Deoxyribose 0.8109 0.6738 1 0.8054 0.5313 0.9331 0.8054 0.8664 0.9372 0.7877
L-Cysteate 0.3489 0.7667 1 0.9331 0.5144 0.4686 0.6147 0.7319 0.4769 0.3174
Chitin 0.1393 0.9289 1 0.5627 0.4769 0.4769 0.6472 0.5486 0.9568 0.5116