Multi-omics Metabolic & Microbiome
Profiling of Mouse Pregnancy

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Metabolic profile vs Metabolic profile

Image 1

Correlation coefficients:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
Body_Wt 1.00000 0.54779 0.23071 -0.13946 0.26437 -0.21862 0.11553 -0.21531 -0.02496 -0.06727 -0.18165 0.13477
Subcutaneous_Fat_Wt 0.54779 1.00000 0.45466 -0.03639 0.02837 -0.30503 -0.13165 -0.03893 0.19603 0.06357 0.06446 0.17894
Visceral_Fat_Wt 0.23071 0.45466 1.00000 0.02172 0.12774 -0.07851 0.07378 0.12239 0.03888 -0.01192 0.20745 0.20271
Pancreas_Wt -0.13946 -0.03639 0.02172 1.00000 -0.19746 0.20254 -0.06972 -0.11250 0.01100 0.04460 0.05106 -0.08871
Insulin_ng_mL 0.26437 0.02837 0.12774 -0.19746 1.00000 -0.02485 0.85521 -0.06550 -0.02374 0.01631 -0.10966 0.03389
Blood_Glucose_mg_dL -0.21862 -0.30503 -0.07851 0.20254 -0.02485 1.00000 0.49610 -0.01260 -0.35367 -0.26527 -0.03269 -0.31689
Real_HOMA_IR 0.11553 -0.13165 0.07378 -0.06972 0.85521 0.49610 1.00000 -0.06150 -0.20042 -0.12544 -0.11034 -0.13882
Serum_Acetate_ug_mL -0.21531 -0.03893 0.12239 -0.11250 -0.06550 -0.01260 -0.06150 1.00000 0.31264 0.22246 0.03031 -0.18250
Serum_Butyrate_ng_mL -0.02496 0.19603 0.03888 0.01100 -0.02374 -0.35367 -0.20042 0.31264 1.00000 0.42408 0.52462 -0.05106
Serum_Propionate_ng_mL -0.06727 0.06357 -0.01192 0.04460 0.01631 -0.26527 -0.12544 0.22246 0.42408 1.00000 0.15475 -0.14830
Serum_Isovalerate_ng_mL -0.18165 0.06446 0.20745 0.05106 -0.10966 -0.03269 -0.11034 0.03031 0.52462 0.15475 1.00000 -0.11986
Liver_Triglycerides_mg_dL 0.13477 0.17894 0.20271 -0.08871 0.03389 -0.31689 -0.13882 -0.18250 -0.05106 -0.14830 -0.11986 1.00000

P-values:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
Body_Wt NA 0.00001 0.08145 0.29645 0.04492 0.09920 0.38780 0.10456 0.85244 0.61583 0.17236 0.32203
Subcutaneous_Fat_Wt 0.00001 NA 0.00038 0.78812 0.83408 0.02104 0.32899 0.77372 0.14390 0.63852 0.63380 0.19116
Visceral_Fat_Wt 0.08145 0.00038 NA 0.87146 0.33929 0.55802 0.58206 0.36005 0.77202 0.92926 0.11816 0.13404
Pancreas_Wt 0.29645 0.78812 0.87146 NA 0.13734 0.12732 0.60303 0.40045 0.93466 0.73955 0.70347 0.51560
Insulin_ng_mL 0.04492 0.83408 0.33929 0.13734 NA 0.85312 0.00000 0.62521 0.85963 0.90330 0.41254 0.80417
Blood_Glucose_mg_dL 0.09920 0.02104 0.55802 0.12732 0.85312 NA 0.00007 0.92523 0.00646 0.04417 0.80754 0.01733
Real_HOMA_IR 0.38780 0.32899 0.58206 0.60303 0.00000 0.00007 NA 0.64653 0.13144 0.34811 0.40961 0.30757
Serum_Acetate_ug_mL 0.10456 0.77372 0.36005 0.40045 0.62521 0.92523 0.64653 NA 0.01688 0.09327 0.82130 0.17822
Serum_Butyrate_ng_mL 0.85244 0.14390 0.77202 0.93466 0.85963 0.00646 0.13144 0.01688 NA 0.00091 0.00002 0.70860
Serum_Propionate_ng_mL 0.61583 0.63852 0.92926 0.73955 0.90330 0.04417 0.34811 0.09327 0.00091 NA 0.24609 0.27536
Serum_Isovalerate_ng_mL 0.17236 0.63380 0.11816 0.70347 0.41254 0.80754 0.40961 0.82130 0.00002 0.24609 NA 0.37890
Liver_Triglycerides_mg_dL 0.32203 0.19116 0.13404 0.51560 0.80417 0.01733 0.30757 0.17822 0.70860 0.27536 0.37890 NA

Metabolic profile vs Differentially significant microbes

Image 2

Correlation coefficients:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
4C0d-2 -0.10785 0.09008 0.36211 0.10200 -0.02746 0.25548 0.10660 0.18014 -0.10006 -0.01445 0.05527 -0.07511
Actinobacteria 0.31356 0.21113 -0.02567 0.10139 0.01060 -0.00976 -0.00775 -0.16849 -0.17617 0.04724 -0.16920 0.02053
Alphaproteobacteria 0.06365 0.19993 0.34677 0.06244 -0.05202 0.16372 0.03861 0.31891 -0.01665 -0.01828 0.06080 0.04368
Bacilli -0.04887 0.10772 -0.19554 0.04434 -0.06663 -0.12447 -0.13188 -0.26365 -0.14113 0.06726 -0.03395 0.14104
Bacteroidia 0.10514 -0.04838 0.01669 -0.13170 0.16171 -0.08622 0.09888 -0.14534 0.15035 0.07414 -0.02157 -0.01809
Betaproteobacteria 0.39596 0.21878 -0.05823 -0.07899 0.25150 -0.23173 0.08861 -0.32838 -0.09489 -0.09521 -0.14131 0.04685
Chloroplast 0.18489 0.15769 0.10928 0.20583 -0.05751 -0.08468 -0.09226 0.10124 0.11906 0.06494 -0.03596 0.15499
Clostridia 0.20241 0.16033 0.00147 0.21797 -0.13107 -0.26957 -0.25676 0.03244 0.24063 0.17077 -0.08717 0.17871
Coriobacteriia 0.16345 0.32323 0.00937 -0.02133 -0.03894 -0.19496 -0.13873 -0.24666 -0.20493 0.09192 -0.13784 0.11165
Cytophagia -0.15742 -0.09672 -0.08276 0.11102 -0.06863 0.32339 0.10555 -0.21899 -0.24170 -0.36185 0.12863 -0.05011
Deferribacteres -0.08465 0.10175 0.37416 0.10629 -0.02861 0.25428 0.10502 0.17551 -0.10402 0.00231 0.05209 -0.06801
Deltaproteobacteria 0.04634 0.02034 0.10358 -0.04115 -0.02340 -0.27540 -0.16382 -0.26741 -0.05301 -0.18162 0.10013 0.70921
Epsilonproteobacteria -0.10785 0.09008 0.36211 0.10200 -0.02746 0.25548 0.10660 0.18014 -0.10006 -0.01445 0.05527 -0.07511
Erysipelotrichi 0.14591 0.03908 -0.12912 -0.28764 0.01853 -0.12963 -0.05162 -0.13541 0.14580 -0.05836 0.06512 -0.00567
Flavobacteriia -0.14025 -0.04158 0.06786 -0.18844 -0.03226 -0.20998 -0.13280 0.20955 0.07559 0.04913 0.04299 -0.09812
Gammaproteobacteria 0.12997 0.34693 0.09624 -0.10193 0.20200 -0.27914 0.02028 0.17696 0.26159 0.18763 0.00176 0.19941
Mollicutes 0.42532 0.32077 0.15236 0.30932 -0.10991 -0.21934 -0.21084 0.05225 0.06659 0.18637 -0.10836 0.08159
TM7-3 -0.10785 0.09008 0.36211 0.10200 -0.02746 0.25548 0.10660 0.18014 -0.10006 -0.01445 0.05527 -0.07511
Unclassified Unassigned 0.10190 0.12150 -0.17123 -0.07012 0.05085 0.05382 0.06931 -0.10388 -0.02025 -0.13722 0.06967 -0.16920
Verrucomicrobiae 0.02646 -0.04004 0.04588 -0.15731 0.18614 -0.04599 0.14150 -0.00290 -0.09378 -0.00919 -0.06586 0.10221

P-values:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
4C0d-2 0.42032 0.50516 0.00522 0.44612 0.83785 0.05292 0.42577 0.17600 0.45486 0.91426 0.68027 0.58221
Actinobacteria 0.01654 0.11491 0.84831 0.44884 0.93707 0.94201 0.95396 0.20613 0.18588 0.72474 0.20419 0.88061
Alphaproteobacteria 0.63500 0.13595 0.00766 0.64150 0.69815 0.21943 0.77353 0.01469 0.90126 0.89167 0.65030 0.74926
Bacilli 0.71565 0.42512 0.14129 0.74101 0.61921 0.35190 0.32373 0.04553 0.29065 0.61593 0.80030 0.29981
Bacteroidia 0.43217 0.72081 0.90102 0.32438 0.22524 0.51989 0.46024 0.27636 0.25994 0.58019 0.87233 0.89470
Betaproteobacteria 0.00209 0.10204 0.66414 0.55559 0.05686 0.08007 0.50833 0.01185 0.47861 0.47711 0.29003 0.73170
Chloroplast 0.16471 0.24140 0.41417 0.12112 0.66808 0.52741 0.49094 0.44952 0.37338 0.62818 0.78868 0.25404
Clostridia 0.12756 0.23350 0.99126 0.10023 0.32673 0.04072 0.05170 0.80896 0.06883 0.19995 0.51525 0.18756
Coriobacteriia 0.22022 0.01419 0.94433 0.87371 0.77167 0.14250 0.29899 0.06196 0.12279 0.49253 0.30214 0.41267
Cytophagia 0.23794 0.47415 0.53681 0.40674 0.60871 0.01328 0.43037 0.09862 0.06757 0.00525 0.33589 0.71380
Deferribacteres 0.52753 0.45137 0.00381 0.42711 0.83117 0.05408 0.43270 0.18756 0.43713 0.98626 0.69778 0.61845
Deltaproteobacteria 0.72977 0.88060 0.43908 0.75907 0.86161 0.03640 0.21915 0.04243 0.69270 0.17243 0.45457 0.00000
Epsilonproteobacteria 0.42032 0.50516 0.00522 0.44612 0.83785 0.05292 0.42577 0.17600 0.45486 0.91426 0.68027 0.58221
Erysipelotrichi 0.27443 0.77288 0.33405 0.02857 0.89017 0.33214 0.70034 0.31081 0.27482 0.66344 0.62721 0.96689
Flavobacteriia 0.29369 0.75879 0.61277 0.15659 0.81005 0.11365 0.32034 0.11441 0.57277 0.71416 0.74863 0.47187
Gammaproteobacteria 0.33083 0.00819 0.47234 0.44642 0.12836 0.03384 0.87990 0.18389 0.04731 0.15843 0.98953 0.14063
Mollicutes 0.00087 0.01499 0.25356 0.01814 0.41147 0.09808 0.11214 0.69689 0.61945 0.16129 0.41812 0.54999
TM7-3 0.42032 0.50516 0.00522 0.44612 0.83785 0.05292 0.42577 0.17600 0.45486 0.91426 0.68027 0.58221
Unclassified Unassigned 0.44655 0.36797 0.19872 0.60096 0.70465 0.68822 0.60515 0.43774 0.88009 0.30433 0.60330 0.21253
Verrucomicrobiae 0.84370 0.76743 0.73233 0.23827 0.16182 0.73174 0.28936 0.98274 0.48380 0.94540 0.62327 0.45350

Differentially significant microbes vs Differentially significant microbes

Image 3

Correlation coefficients:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia Deferribacteres Deltaproteobacteria Epsilonproteobacteria Erysipelotrichi Flavobacteriia Gammaproteobacteria Mollicutes TM7-3 Unclassified Unassigned Verrucomicrobiae
4C0d-2 1.00000 0.07143 0.80471 0.07880 -0.08724 -0.14036 -0.04834 -0.11226 -0.08212 -0.03952 0.99837 0.04396 1.00000 -0.01814 -0.01754 -0.09312 0.04403 1.00000 0.15801 -0.08070
Actinobacteria 0.07143 1.00000 0.01550 0.36111 0.06565 0.42196 -0.16065 0.14236 0.44685 0.14608 0.09518 -0.07003 0.07143 -0.07383 -0.05856 0.02605 0.07338 0.07143 0.36846 -0.00065
Alphaproteobacteria 0.80471 0.01550 1.00000 -0.01072 -0.15445 -0.18636 0.22130 -0.02070 -0.15663 -0.08965 0.80675 0.00259 0.80471 -0.10064 -0.03980 -0.00649 0.20355 0.80471 0.07110 0.04917
Bacilli 0.07880 0.36111 -0.01072 1.00000 0.03546 0.25115 -0.07775 0.00188 0.25545 0.24698 0.07814 0.09720 0.07880 0.20236 -0.07205 0.10796 -0.02803 0.07880 0.28634 -0.01966
Bacteroidia -0.08724 0.06565 -0.15445 0.03546 1.00000 0.37873 -0.02994 -0.26459 0.09128 -0.22372 -0.08453 -0.10079 -0.08724 0.21212 -0.11004 0.07636 -0.29417 -0.08724 0.14983 0.35152
Betaproteobacteria -0.14036 0.42196 -0.18636 0.25115 0.37873 1.00000 -0.15015 -0.14242 0.48920 -0.10938 -0.13734 -0.15565 -0.14036 0.40541 -0.09433 0.25426 -0.09581 -0.14036 0.17904 0.14248
Chloroplast -0.04834 -0.16065 0.22130 -0.07775 -0.02994 -0.15015 1.00000 0.13116 -0.12953 -0.10889 -0.05107 -0.06493 -0.04834 -0.06392 -0.04834 0.07413 0.20612 -0.04834 -0.08854 0.05121
Clostridia -0.11226 0.14236 -0.02070 0.00188 -0.26459 -0.14242 0.13116 1.00000 -0.16301 -0.03909 -0.10431 0.14096 -0.11226 -0.08207 0.10808 0.14941 0.47261 -0.11226 -0.11518 -0.25763
Coriobacteriia -0.08212 0.44685 -0.15663 0.25545 0.09128 0.48920 -0.12953 -0.16301 1.00000 -0.01025 -0.07420 -0.06909 -0.08212 -0.03037 -0.03632 0.22854 -0.09022 -0.08212 0.16538 0.14215
Cytophagia -0.03952 0.14608 -0.08965 0.24698 -0.22372 -0.10938 -0.10889 -0.03909 -0.01025 1.00000 -0.04175 0.13399 -0.03952 -0.07887 -0.03952 -0.20975 -0.12705 -0.03952 0.14809 -0.01899
Deferribacteres 0.99837 0.09518 0.80675 0.07814 -0.08453 -0.13734 -0.05107 -0.10431 -0.07420 -0.04175 1.00000 0.04258 0.99837 -0.02281 -0.01853 -0.09838 0.05334 0.99837 0.15547 -0.08409
Deltaproteobacteria 0.04396 -0.07003 0.00259 0.09720 -0.10079 -0.15565 -0.06493 0.14096 -0.06909 0.13399 0.04258 1.00000 0.04396 -0.04553 -0.02356 -0.12506 0.12550 0.04396 0.07169 -0.10703
Epsilonproteobacteria 1.00000 0.07143 0.80471 0.07880 -0.08724 -0.14036 -0.04834 -0.11226 -0.08212 -0.03952 0.99837 0.04396 1.00000 -0.01814 -0.01754 -0.09312 0.04403 1.00000 0.15801 -0.08070
Erysipelotrichi -0.01814 -0.07383 -0.10064 0.20236 0.21212 0.40541 -0.06392 -0.08207 -0.03037 -0.07887 -0.02281 -0.04553 -0.01814 1.00000 0.04251 0.01697 -0.14766 -0.01814 0.06316 0.01073
Flavobacteriia -0.01754 -0.05856 -0.03980 -0.07205 -0.11004 -0.09433 -0.04834 0.10808 -0.03632 -0.03952 -0.01853 -0.02356 -0.01754 0.04251 1.00000 0.10691 -0.09948 -0.01754 -0.04276 -0.08070
Gammaproteobacteria -0.09312 0.02605 -0.00649 0.10796 0.07636 0.25426 0.07413 0.14941 0.22854 -0.20975 -0.09838 -0.12506 -0.09312 0.01697 0.10691 1.00000 0.00701 -0.09312 0.00840 -0.06532
Mollicutes 0.04403 0.07338 0.20355 -0.02803 -0.29417 -0.09581 0.20612 0.47261 -0.09022 -0.12705 0.05334 0.12550 0.04403 -0.14766 -0.09948 0.00701 1.00000 0.04403 -0.13541 -0.30825
TM7-3 1.00000 0.07143 0.80471 0.07880 -0.08724 -0.14036 -0.04834 -0.11226 -0.08212 -0.03952 0.99837 0.04396 1.00000 -0.01814 -0.01754 -0.09312 0.04403 1.00000 0.15801 -0.08070
Unclassified Unassigned 0.15801 0.36846 0.07110 0.28634 0.14983 0.17904 -0.08854 -0.11518 0.16538 0.14809 0.15547 0.07169 0.15801 0.06316 -0.04276 0.00840 -0.13541 0.15801 1.00000 -0.09546
Verrucomicrobiae -0.08070 -0.00065 0.04917 -0.01966 0.35152 0.14248 0.05121 -0.25763 0.14215 -0.01899 -0.08409 -0.10703 -0.08070 0.01073 -0.08070 -0.06532 -0.30825 -0.08070 -0.09546 1.00000

P-values:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia Deferribacteres Deltaproteobacteria Epsilonproteobacteria Erysipelotrichi Flavobacteriia Gammaproteobacteria Mollicutes TM7-3 Unclassified Unassigned Verrucomicrobiae
4C0d-2 NA 0.59416 0.00000 0.55656 0.51492 0.29332 0.71857 0.40148 0.54001 0.76836 0.00000 0.74319 0.00000 0.89247 0.89600 0.48691 0.74277 0.00000 0.23615 0.54706
Actinobacteria 0.59416 NA 0.90807 0.00535 0.62442 0.00097 0.22834 0.28641 0.00044 0.27386 0.47725 0.60144 0.59416 0.58179 0.66235 0.84610 0.58408 0.59416 0.00443 0.99611
Alphaproteobacteria 0.00000 0.90807 NA 0.93634 0.24702 0.16131 0.09503 0.87745 0.24032 0.50336 0.00000 0.98462 0.00000 0.45224 0.76676 0.96145 0.12539 0.00000 0.59587 0.71396
Bacilli 0.55656 0.00535 0.93634 NA 0.79157 0.05722 0.56186 0.98884 0.05295 0.06161 0.55986 0.46792 0.55656 0.12766 0.59092 0.41986 0.83453 0.55656 0.02932 0.88351
Bacteroidia 0.51492 0.62442 0.24702 0.79157 NA 0.00337 0.82346 0.04473 0.49558 0.09137 0.52811 0.45158 0.51492 0.10992 0.41092 0.56885 0.02500 0.51492 0.26160 0.00682
Betaproteobacteria 0.29332 0.00097 0.16131 0.05722 0.00337 NA 0.26059 0.28622 0.00010 0.41376 0.30392 0.24331 0.29332 0.00159 0.48124 0.05411 0.47436 0.29332 0.17870 0.28601
Chloroplast 0.71857 0.22834 0.09503 0.56186 0.82346 0.26059 NA 0.32641 0.33251 0.41583 0.70339 0.62824 0.71857 0.63356 0.71857 0.58026 0.12059 0.71857 0.50865 0.70261
Clostridia 0.40148 0.28641 0.87745 0.98884 0.04473 0.28622 0.32641 NA 0.22147 0.77083 0.43586 0.29122 0.40148 0.54022 0.41933 0.26298 0.00018 0.40148 0.38927 0.05089
Coriobacteriia 0.54001 0.00044 0.24032 0.05295 0.49558 0.00010 0.33251 0.22147 NA 0.93914 0.57989 0.60632 0.54001 0.82097 0.78664 0.08443 0.50061 0.54001 0.21474 0.28713
Cytophagia 0.76836 0.27386 0.50336 0.06161 0.09137 0.41376 0.41583 0.77083 0.93914 NA 0.75567 0.31597 0.76836 0.55622 0.76836 0.11405 0.34192 0.76836 0.26725 0.88746
Deferribacteres 0.00000 0.47725 0.00000 0.55986 0.52811 0.30392 0.70339 0.43586 0.57989 0.75567 NA 0.75095 0.00000 0.86507 0.89017 0.46253 0.69088 0.00000 0.24387 0.53027
Deltaproteobacteria 0.74319 0.60144 0.98462 0.46792 0.45158 0.24331 0.62824 0.29122 0.60632 0.31597 0.75095 NA 0.74319 0.73434 0.86064 0.34960 0.34791 0.74319 0.59279 0.42392
Epsilonproteobacteria 0.00000 0.59416 0.00000 0.55656 0.51492 0.29332 0.71857 0.40148 0.54001 0.76836 0.00000 0.74319 NA 0.89247 0.89600 0.48691 0.74277 0.00000 0.23615 0.54706
Erysipelotrichi 0.89247 0.58179 0.45224 0.12766 0.10992 0.00159 0.63356 0.54022 0.82097 0.55622 0.86507 0.73434 0.89247 NA 0.75137 0.89939 0.26867 0.89247 0.63766 0.93628
Flavobacteriia 0.89600 0.66235 0.76676 0.59092 0.41092 0.48124 0.71857 0.41933 0.78664 0.76836 0.89017 0.86064 0.89600 0.75137 NA 0.42441 0.45749 0.89600 0.74994 0.54706
Gammaproteobacteria 0.48691 0.84610 0.96145 0.41986 0.56885 0.05411 0.58026 0.26298 0.08443 0.11405 0.46253 0.34960 0.48691 0.89939 0.42441 NA 0.95834 0.48691 0.95012 0.62617
Mollicutes 0.74277 0.58408 0.12539 0.83453 0.02500 0.47436 0.12059 0.00018 0.50061 0.34192 0.69088 0.34791 0.74277 0.26867 0.45749 0.95834 NA 0.74277 0.31082 0.01857
TM7-3 0.00000 0.59416 0.00000 0.55656 0.51492 0.29332 0.71857 0.40148 0.54001 0.76836 0.00000 0.74319 0.00000 0.89247 0.89600 0.48691 0.74277 NA 0.23615 0.54706
Unclassified Unassigned 0.23615 0.00443 0.59587 0.02932 0.26160 0.17870 0.50865 0.38927 0.21474 0.26725 0.24387 0.59279 0.23615 0.63766 0.74994 0.95012 0.31082 0.23615 NA 0.47596
Verrucomicrobiae 0.54706 0.99611 0.71396 0.88351 0.00682 0.28601 0.70261 0.05089 0.28713 0.88746 0.53027 0.42392 0.54706 0.93628 0.54706 0.62617 0.01857 0.54706 0.47596 NA

Metabolic profile vs Metabolic profile

Image 1

Correlation coefficients:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
Body_Wt 1 0.5576 0.005 0.0703 -0.1763 -0.2747 -0.2312 -0.4968 -0.2503 -0.0986 -0.2828 -0.2689
Subcutaneous_Fat_Wt 0.5576 1 -0.1266 0.0189 0.0742 -0.3291 0.01 -0.3249 -0.0237 0.0817 -0.0826 -0.3098
Visceral_Fat_Wt 0.005 -0.1266 1 0.1741 0.0061 0.2326 0.0452 0.0509 -0.105 -0.1021 0.0875 0.2018
Pancreas_Wt 0.0703 0.0189 0.1741 1 -0.0564 0.1821 -0.0148 0.0459 0.0927 -0.064 0.0456 -0.1033
Insulin_ng_mL -0.1763 0.0742 0.0061 -0.0564 1 0.0672 0.976 0.2 0.1243 0.5391 0.4961 0.0275
Blood_Glucose_mg_dL -0.2747 -0.3291 0.2326 0.1821 0.0672 1 0.2777 0.0658 0.1668 0.0125 0.0478 0.2851
Real_HOMA_IR -0.2312 0.01 0.0452 -0.0148 0.976 0.2777 1 0.2121 0.1611 0.5245 0.479 0.0848
Serum_Acetate_ug_mL -0.4968 -0.3249 0.0509 0.0459 0.2 0.0658 0.2121 1 0.2375 0.3348 0.0525 0.0357
Serum_Butyrate_ng_mL -0.2503 -0.0237 -0.105 0.0927 0.1243 0.1668 0.1611 0.2375 1 0.2117 0.4507 -0.0196
Serum_Propionate_ng_mL -0.0986 0.0817 -0.1021 -0.064 0.5391 0.0125 0.5245 0.3348 0.2117 1 0.2321 -0.0402
Serum_Isovalerate_ng_mL -0.2828 -0.0826 0.0875 0.0456 0.4961 0.0478 0.479 0.0525 0.4507 0.2321 1 -0.1141
Liver_Triglycerides_mg_dL -0.2689 -0.3098 0.2018 -0.1033 0.0275 0.2851 0.0848 0.0357 -0.0196 -0.0402 -0.1141 1

P-values:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
Body_Wt NA 0 0.9698 0.5999 0.1817 0.0336 0.0781 1e-04 0.0559 0.4574 0.03 0.0413
Subcutaneous_Fat_Wt 0 NA 0.3393 0.8878 0.5764 0.0109 0.94 0.012 0.8583 0.5382 0.5339 0.019
Visceral_Fat_Wt 0.9698 0.3393 NA 0.1911 0.9633 0.0762 0.734 0.7019 0.4285 0.4415 0.5097 0.1321
Pancreas_Wt 0.5999 0.8878 0.1911 NA 0.6739 0.1712 0.9125 0.732 0.4891 0.6333 0.7342 0.4487
Insulin_ng_mL 0.1817 0.5764 0.9633 0.6739 NA 0.6128 0 0.1289 0.3481 0 1e-04 0.8393
Blood_Glucose_mg_dL 0.0336 0.0109 0.0762 0.1712 0.6128 NA 0.0332 0.6203 0.2068 0.925 0.7193 0.0301
Real_HOMA_IR 0.0781 0.94 0.734 0.9125 0 0.0332 NA 0.1069 0.223 0 1e-04 0.5306
Serum_Acetate_ug_mL 1e-04 0.012 0.7019 0.732 0.1289 0.6203 0.1069 NA 0.0701 0.0095 0.6931 0.7923
Serum_Butyrate_ng_mL 0.0559 0.8583 0.4285 0.4891 0.3481 0.2068 0.223 0.0701 NA 0.1075 3e-04 0.8851
Serum_Propionate_ng_mL 0.4574 0.5382 0.4415 0.6333 0 0.925 0 0.0095 0.1075 NA 0.0769 0.7666
Serum_Isovalerate_ng_mL 0.03 0.5339 0.5097 0.7342 1e-04 0.7193 1e-04 0.6931 3e-04 0.0769 NA 0.3979
Liver_Triglycerides_mg_dL 0.0413 0.019 0.1321 0.4487 0.8393 0.0301 0.5306 0.7923 0.8851 0.7666 0.3979 NA

Metabolic profile vs Differentialy significant microbes

Image 2

Correlation coefficients:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
4C0d-2 -0.0973 -0.041 0.0395 0.0624 -0.0308 0.0557 -0.0181 -0.0757 0.235 -0.0466 0.464 -5e-04
Actinobacteria 0.2277 0.1374 -0.053 0.0086 0.1276 -0.083 0.0961 -0.199 -0.0837 -0.0165 0.1916 -0.1194
Alphaproteobacteria -0.0964 -0.0737 0.0334 0.0611 -0.0353 0.0731 -0.0205 0.0837 0.1229 -0.0034 0.1948 -0.0628
Bacilli -0.0586 -0.1497 -0.1392 0.0797 0.0543 -0.1802 0.006 0.0209 0.0212 -0.0785 0.2071 -0.2075
Bacteroidia 0.0807 -0.1593 0.096 0.1896 -0.046 -0.0293 -0.0604 0.0366 -0.2026 -0.1606 0.04 -0.0295
Betaproteobacteria 0.1072 -0.2349 0.1565 0.1173 -0.1867 -0.0328 -0.1908 0.0132 -0.1494 -0.0779 -0.1154 -0.0554
Chloroplast -0.0148 0.0118 0.0044 0.0585 0.0231 -0.0012 0.0218 -0.056 0.2284 -0.0253 0.4099 -0.018
Clostridia 0.018 0.2182 0.0859 0.0827 -0.1966 -0.1611 -0.215 -0.0389 -0.0507 -0.3135 -0.1864 0.0147
Coriobacteriia 0.0869 -0.0016 0.1016 -0.1215 -0.0896 -0.0463 -0.0901 -0.0384 -0.1927 -0.0853 -0.1282 -0.0446
Cytophagia -0.0945 -0.043 0.0139 0.1076 0.1647 -0.0102 0.1594 0.0587 -0.1324 -0.0758 0.1544 -0.1312
Deferribacteres 0.3014 0.3581 -0.1639 -0.0853 -0.1535 -0.3707 -0.2286 -0.2049 -0.0139 -0.0886 -0.1612 0.0168
Deltaproteobacteria -0.1368 -0.0639 -0.0073 0.0653 -0.0518 -0.0065 -0.0515 -0.0864 0.1477 -0.0947 0.3591 -0.0469
Epsilonproteobacteria -0.1936 -0.0885 -0.1537 -0.067 0.0741 0.0548 0.0788 0.1382 0.2745 0.1208 0.1246 -0.1919
Erysipelotrichi -0.2164 -0.1551 0.0471 0.1276 -0.1515 -0.0148 -0.152 0.2047 -0.198 -0.1749 -0.075 0.0045
Flavobacteriia -0.0957 -0.042 0.0616 0.0034 -0.0624 -0.0915 -0.079 -0.1017 0.0829 -0.1068 0.0192 -0.0987
Gammaproteobacteria -0.0981 -0.0556 0.0228 0.0654 -0.0373 0.0291 -0.0299 -0.0818 0.2196 -0.066 0.4557 -0.0229
Mollicutes 0.0852 -0.0128 0.0474 0.0605 0.2504 0.1465 0.2622 -0.0226 -0.0592 -0.1055 0.1014 0.012
TM7-3 -0.0595 0.0312 0.1293 0.0775 0.3239 -0.021 0.2993 0.0146 0.1248 -0.0364 0.3829 -0.1125
Unclassified Unassigned 0.2744 0.2173 -0.103 -0.0062 -0.1471 0.2236 -0.0955 -0.1366 0.2474 -0.0441 -0.1104 -0.132
Verrucomicrobiae -0.061 -0.235 0.083 -0.0067 0.2476 0.2624 0.2854 0.2001 -0.1344 6e-04 -0.0657 0.1499

P-values:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
4C0d-2 0.4596 0.7581 0.7664 0.6415 0.8169 0.6724 0.8915 0.569 0.0732 0.726 2e-04 0.9973
Actinobacteria 0.0801 0.2992 0.6904 0.949 0.3353 0.5282 0.4692 0.1309 0.5286 0.9011 0.1461 0.372
Alphaproteobacteria 0.4639 0.5791 0.8016 0.6487 0.7905 0.5789 0.8778 0.5285 0.3539 0.9796 0.1392 0.6396
Bacilli 0.6568 0.2579 0.293 0.552 0.6829 0.1684 0.9641 0.8754 0.8735 0.5547 0.1156 0.1181
Bacteroidia 0.5401 0.2281 0.4695 0.1539 0.7294 0.8242 0.6496 0.7831 0.1238 0.2245 0.7636 0.8259
Betaproteobacteria 0.415 0.0734 0.2364 0.3807 0.1568 0.8036 0.1477 0.9212 0.2586 0.5573 0.3841 0.6798
Chloroplast 0.9103 0.9293 0.9738 0.6627 0.8622 0.9926 0.87 0.6737 0.0819 0.8494 0.0013 0.8936
Clostridia 0.8916 0.0969 0.5179 0.537 0.1356 0.2189 0.102 0.7697 0.703 0.0156 0.1574 0.9131
Coriobacteriia 0.5089 0.9902 0.4438 0.3634 0.4999 0.7253 0.4972 0.7728 0.1436 0.5208 0.3334 0.7396
Cytophagia 0.4726 0.7466 0.9169 0.4215 0.2124 0.9385 0.228 0.6587 0.3174 0.568 0.2429 0.3261
Deferribacteres 0.0193 0.0054 0.2148 0.5245 0.2459 0.0036 0.0816 0.1196 0.917 0.5043 0.2226 0.9004
Deltaproteobacteria 0.2973 0.6304 0.956 0.6263 0.6967 0.9607 0.6984 0.5151 0.2642 0.4754 0.0052 0.7266
Epsilonproteobacteria 0.1382 0.5051 0.2453 0.6174 0.5769 0.6776 0.5531 0.2964 0.0354 0.3623 0.3471 0.1489
Erysipelotrichi 0.0968 0.2409 0.7233 0.3398 0.2521 0.9104 0.2504 0.12 0.1328 0.1853 0.5722 0.9733
Flavobacteriia 0.4672 0.752 0.6428 0.9797 0.6387 0.4869 0.5518 0.4435 0.5324 0.4209 0.8855 0.4611
Gammaproteobacteria 0.4559 0.6756 0.8639 0.6259 0.7789 0.8251 0.822 0.5379 0.0948 0.6197 3e-04 0.8643
Mollicutes 0.5176 0.9236 0.7214 0.6517 0.0558 0.2641 0.0448 0.8648 0.6558 0.4265 0.4446 0.9288
TM7-3 0.6514 0.8148 0.3289 0.5633 0.0123 0.8737 0.0213 0.9126 0.3461 0.7846 0.0028 0.4003
Unclassified Unassigned 0.0338 0.0983 0.4377 0.9631 0.2663 0.0858 0.4718 0.3021 0.0588 0.7399 0.4052 0.3234
Verrucomicrobiae 0.6434 0.0732 0.5322 0.9602 0.0587 0.0428 0.0284 0.1286 0.3102 0.9964 0.6212 0.2615

Differentially significant microbes vs Differentially significant microbes

Image 3

Correlation coefficients:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia Deferribacteres Deltaproteobacteria Epsilonproteobacteria Erysipelotrichi Flavobacteriia Gammaproteobacteria Mollicutes TM7-3 Unclassified Unassigned Verrucomicrobiae
4C0d-2 1 -0.054 0.4756 0.1274 -0.111 -0.047 0.9576 -0.0194 -0.0848 0.0246 -0.0756 0.6969 -0.0384 -0.1205 -0.0242 0.9904 -0.0476 0.0073 -0.0199 -0.0289
Actinobacteria -0.054 1 -0.0942 0.3778 0.3779 0.0971 -0.0897 -0.0767 0.1158 0.2126 0.0119 0.0161 0.1212 -0.0861 0.087 -0.052 0.1787 0.383 -0.0261 -0.1003
Alphaproteobacteria 0.4756 -0.0942 1 0.2126 0.0772 0.39 0.4503 -0.1133 -0.0635 0.0296 -0.1253 0.3146 -0.0714 -0.1286 -0.0449 0.4627 -0.023 0.1444 -0.0679 0.0905
Bacilli 0.1274 0.3778 0.2126 1 0.3068 0.1729 0.0784 0.1121 -0.1126 0.1945 -0.0632 0.0676 0.1949 0.1077 0.0097 0.14 0.236 0.4854 -0.0742 -0.0394
Bacteroidia -0.111 0.3779 0.0772 0.3068 1 0.1777 -0.1649 -0.0153 0.2837 0.5858 -0.0936 -0.0703 0.2926 0.2985 -0.0822 -0.0969 0.4545 0.6292 -0.0724 -0.004
Betaproteobacteria -0.047 0.0971 0.39 0.1729 0.1777 1 -0.0785 0.0677 0.0571 0.1065 -0.0682 0.1832 -0.0822 0.1742 0.1048 -0.0132 -0.2215 0.0357 -0.2893 0.0402
Chloroplast 0.9576 -0.0897 0.4503 0.0784 -0.1649 -0.0785 1 -0.0178 -0.1137 0.0152 -0.0414 0.6602 -0.0594 -0.1736 -0.0374 0.9464 0.009 -0.0105 0.0466 0.0379
Clostridia -0.0194 -0.0767 -0.1133 0.1121 -0.0153 0.0677 -0.0178 1 0.1418 0.074 0.3964 0.0924 -0.0264 0.2393 0.3232 0.0068 -0.1833 0.1054 -0.014 -0.2375
Coriobacteriia -0.0848 0.1158 -0.0635 -0.1126 0.2837 0.0571 -0.1137 0.1418 1 0.1703 0.0403 -0.106 -0.0617 0.1971 0.342 -0.0878 0.1089 0.0268 0.0926 -0.0237
Cytophagia 0.0246 0.2126 0.0296 0.1945 0.5858 0.1065 0.0152 0.074 0.1703 1 -0.1705 0.0773 0.2559 0.1473 0.0771 0.0455 0.265 0.501 -0.0232 -0.032
Deferribacteres -0.0756 0.0119 -0.1253 -0.0632 -0.0936 -0.0682 -0.0414 0.3964 0.0403 -0.1705 1 -0.117 -0.1044 -0.0817 0.2415 -0.0649 -0.181 -0.1055 0.0529 -0.1326
Deltaproteobacteria 0.6969 0.0161 0.3146 0.0676 -0.0703 0.1832 0.6602 0.0924 -0.106 0.0773 -0.117 1 -0.0548 0.2656 -0.0345 0.7617 -0.0999 -0.0166 -0.0729 -0.0412
Epsilonproteobacteria -0.0384 0.1212 -0.0714 0.1949 0.2926 -0.0822 -0.0594 -0.0264 -0.0617 0.2559 -0.1044 -0.0548 1 0.1135 -0.0548 -0.0492 0.1272 0.3009 0.1639 -0.0655
Erysipelotrichi -0.1205 -0.0861 -0.1286 0.1077 0.2985 0.1742 -0.1736 0.2393 0.1971 0.1473 -0.0817 0.2656 0.1135 1 -0.0079 -0.0624 0.1797 0.0755 -0.245 0.0957
Flavobacteriia -0.0242 0.087 -0.0449 0.0097 -0.0822 0.1048 -0.0374 0.3232 0.342 0.0771 0.2415 -0.0345 -0.0548 -0.0079 1 0.0138 -0.1122 -0.0433 -0.062 -0.0412
Gammaproteobacteria 0.9904 -0.052 0.4627 0.14 -0.0969 -0.0132 0.9464 0.0068 -0.0878 0.0455 -0.0649 0.7617 -0.0492 -0.0624 0.0138 1 -0.0457 -0.0023 -0.0369 -0.0309
Mollicutes -0.0476 0.1787 -0.023 0.236 0.4545 -0.2215 0.009 -0.1833 0.1089 0.265 -0.181 -0.0999 0.1272 0.1797 -0.1122 -0.0457 1 0.5333 0.0647 0.4474
TM7-3 0.0073 0.383 0.1444 0.4854 0.6292 0.0357 -0.0105 0.1054 0.0268 0.501 -0.1055 -0.0166 0.3009 0.0755 -0.0433 -0.0023 0.5333 1 -0.0023 -0.0516
Unclassified Unassigned -0.0199 -0.0261 -0.0679 -0.0742 -0.0724 -0.2893 0.0466 -0.014 0.0926 -0.0232 0.0529 -0.0729 0.1639 -0.245 -0.062 -0.0369 0.0647 -0.0023 1 -0.1125
Verrucomicrobiae -0.0289 -0.1003 0.0905 -0.0394 -0.004 0.0402 0.0379 -0.2375 -0.0237 -0.032 -0.1326 -0.0412 -0.0655 0.0957 -0.0412 -0.0309 0.4474 -0.0516 -0.1125 1

P-values:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia Deferribacteres Deltaproteobacteria Epsilonproteobacteria Erysipelotrichi Flavobacteriia Gammaproteobacteria Mollicutes TM7-3 Unclassified Unassigned Verrucomicrobiae
4C0d-2 NA 0.6822 1e-04 0.3321 0.3983 0.7212 0 0.8828 0.5194 0.8522 0.5661 0 0.7709 0.359 0.8545 0 0.7178 0.9557 0.8798 0.8265
Actinobacteria 0.6822 NA 0.4741 0.0029 0.0029 0.4604 0.4954 0.5604 0.3781 0.1029 0.9279 0.9028 0.3565 0.5132 0.5084 0.6934 0.1718 0.0025 0.843 0.4458
Alphaproteobacteria 1e-04 0.4741 NA 0.1029 0.5578 0.0021 3e-04 0.3889 0.6298 0.8222 0.3402 0.0143 0.588 0.3273 0.7332 2e-04 0.8615 0.2711 0.6061 0.4915
Bacilli 0.3321 0.0029 0.1029 NA 0.0171 0.1864 0.5516 0.394 0.3917 0.1364 0.6313 0.608 0.1356 0.4127 0.9413 0.2861 0.0695 1e-04 0.5731 0.765
Bacteroidia 0.3983 0.0029 0.5578 0.0171 NA 0.1743 0.2079 0.9074 0.028 0 0.477 0.5937 0.0233 0.0205 0.5323 0.4613 3e-04 0 0.5825 0.9756
Betaproteobacteria 0.7212 0.4604 0.0021 0.1864 0.1743 NA 0.5512 0.6074 0.6645 0.4182 0.6046 0.1613 0.5322 0.1832 0.4254 0.9206 0.089 0.7864 0.025 0.7603
Chloroplast 0 0.4954 3e-04 0.5516 0.2079 0.5512 NA 0.8926 0.3869 0.9082 0.7534 0 0.652 0.1847 0.7765 0 0.9455 0.9364 0.7235 0.7736
Clostridia 0.8828 0.5604 0.3889 0.394 0.9074 0.6074 0.8926 NA 0.2798 0.5743 0.0017 0.4825 0.8416 0.0655 0.0118 0.959 0.1609 0.4227 0.9154 0.0676
Coriobacteriia 0.5194 0.3781 0.6298 0.3917 0.028 0.6645 0.3869 0.2798 NA 0.1934 0.7598 0.4204 0.6398 0.1313 0.0075 0.5046 0.4074 0.8388 0.4814 0.8575
Cytophagia 0.8522 0.1029 0.8222 0.1364 0 0.4182 0.9082 0.5743 0.1934 NA 0.1928 0.557 0.0484 0.2614 0.5583 0.7301 0.0407 0 0.8602 0.8084
Deferribacteres 0.5661 0.9279 0.3402 0.6313 0.477 0.6046 0.7534 0.0017 0.7598 0.1928 NA 0.3735 0.4272 0.5348 0.063 0.6223 0.1665 0.4223 0.6879 0.3123
Deltaproteobacteria 0 0.9028 0.0143 0.608 0.5937 0.1613 0 0.4825 0.4204 0.557 0.3735 NA 0.6777 0.0402 0.7937 0 0.4477 0.9 0.5801 0.7545
Epsilonproteobacteria 0.7709 0.3565 0.588 0.1356 0.0233 0.5322 0.652 0.8416 0.6398 0.0484 0.4272 0.6777 NA 0.3878 0.6777 0.7088 0.3327 0.0195 0.211 0.6193
Erysipelotrichi 0.359 0.5132 0.3273 0.4127 0.0205 0.1832 0.1847 0.0655 0.1313 0.2614 0.5348 0.0402 0.3878 NA 0.9525 0.6356 0.1694 0.5665 0.0592 0.4669
Flavobacteriia 0.8545 0.5084 0.7332 0.9413 0.5323 0.4254 0.7765 0.0118 0.0075 0.5583 0.063 0.7937 0.6777 0.9525 NA 0.9169 0.3934 0.7427 0.6378 0.7545
Gammaproteobacteria 0 0.6934 2e-04 0.2861 0.4613 0.9206 0 0.959 0.5046 0.7301 0.6223 0 0.7088 0.6356 0.9169 NA 0.7286 0.9858 0.7795 0.8146
Mollicutes 0.7178 0.1718 0.8615 0.0695 3e-04 0.089 0.9455 0.1609 0.4074 0.0407 0.1665 0.4477 0.3327 0.1694 0.3934 0.7286 NA 0 0.6232 3e-04
TM7-3 0.9557 0.0025 0.2711 1e-04 0 0.7864 0.9364 0.4227 0.8388 0 0.4223 0.9 0.0195 0.5665 0.7427 0.9858 0 NA 0.9863 0.6954
Unclassified Unassigned 0.8798 0.843 0.6061 0.5731 0.5825 0.025 0.7235 0.9154 0.4814 0.8602 0.6879 0.5801 0.211 0.0592 0.6378 0.7795 0.6232 0.9863 NA 0.392
Verrucomicrobiae 0.8265 0.4458 0.4915 0.765 0.9756 0.7603 0.7736 0.0676 0.8575 0.8084 0.3123 0.7545 0.6193 0.4669 0.7545 0.8146 3e-04 0.6954 0.392 NA
  • NIH-Swiss

Metabolic profile vs Metabolic profile

Image 1

Correlation coefficients:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
Body_Wt 1 0.6636 -0.1127 0.0071 0.0807 -0.2094 0.0756 0.2952 0.0507 0.0904 -0.1712 -0.1909
Subcutaneous_Fat_Wt 0.6636 1 -0.0656 0.2474 0.1833 -0.2705 0.1704 0.1471 0.2787 0.1988 0.0297 -0.203
Visceral_Fat_Wt -0.1127 -0.0656 1 -0.0564 -0.1331 0.3389 -0.0983 0.0765 0.099 -0.0283 -0.0567 0.2019
Pancreas_Wt 0.0071 0.2474 -0.0564 1 0.2639 -0.1383 0.2426 -0.0563 0.0166 0.0137 0.3174 0.1785
Insulin_ng_mL 0.0807 0.1833 -0.1331 0.2639 1 -0.0712 0.9918 -0.0399 0.054 0.1608 -0.1402 -0.0384
Blood_Glucose_mg_dL -0.2094 -0.2705 0.3389 -0.1383 -0.0712 1 0.0357 -0.0941 0.0501 -0.2812 -0.081 0.0594
Real_HOMA_IR 0.0756 0.1704 -0.0983 0.2426 0.9918 0.0357 1 -0.0481 0.0764 0.1375 -0.1435 -0.0352
Serum_Acetate_ug_mL 0.2952 0.1471 0.0765 -0.0563 -0.0399 -0.0941 -0.0481 1 0.2201 0.3172 -0.1869 -0.168
Serum_Butyrate_ng_mL 0.0507 0.2787 0.099 0.0166 0.054 0.0501 0.0764 0.2201 1 0.1924 0.476 0.0758
Serum_Propionate_ng_mL 0.0904 0.1988 -0.0283 0.0137 0.1608 -0.2812 0.1375 0.3172 0.1924 1 -0.1543 -0.1971
Serum_Isovalerate_ng_mL -0.1712 0.0297 -0.0567 0.3174 -0.1402 -0.081 -0.1435 -0.1869 0.476 -0.1543 1 0.1313
Liver_Triglycerides_mg_dL -0.1909 -0.203 0.2019 0.1785 -0.0384 0.0594 -0.0352 -0.168 0.0758 -0.1971 0.1313 1

P-values:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
Body_Wt NA 0 0.3914 0.957 0.5435 0.1083 0.5695 0.0232 0.703 0.4958 0.1947 0.1439
Subcutaneous_Fat_Wt 0 NA 0.6184 0.0567 0.1645 0.0366 0.197 0.2664 0.0326 0.1313 0.8233 0.1197
Visceral_Fat_Wt 0.3914 0.6184 NA 0.6688 0.315 0.0081 0.4588 0.5648 0.4555 0.8315 0.6697 0.1218
Pancreas_Wt 0.957 0.0567 0.6688 NA 0.0434 0.2918 0.0641 0.672 0.9009 0.9182 0.0143 0.1723
Insulin_ng_mL 0.5435 0.1645 0.315 0.0434 NA 0.5922 0 0.7662 0.6873 0.2278 0.2939 0.773
Blood_Glucose_mg_dL 0.1083 0.0366 0.0081 0.2918 0.5922 NA 0.7885 0.4786 0.706 0.031 0.542 0.6522
Real_HOMA_IR 0.5695 0.197 0.4588 0.0641 0 0.7885 NA 0.72 0.5689 0.3033 0.2827 0.7915
Serum_Acetate_ug_mL 0.0232 0.2664 0.5648 0.672 0.7662 0.4786 0.72 NA 0.0938 0.0144 0.1565 0.2033
Serum_Butyrate_ng_mL 0.703 0.0326 0.4555 0.9009 0.6873 0.706 0.5689 0.0938 NA 0.1444 1e-04 0.5681
Serum_Propionate_ng_mL 0.4958 0.1313 0.8315 0.9182 0.2278 0.031 0.3033 0.0144 0.1444 NA 0.2433 0.1345
Serum_Isovalerate_ng_mL 0.1947 0.8233 0.6697 0.0143 0.2939 0.542 0.2827 0.1565 1e-04 0.2433 NA 0.3217
Liver_Triglycerides_mg_dL 0.1439 0.1197 0.1218 0.1723 0.773 0.6522 0.7915 0.2033 0.5681 0.1345 0.3217 NA

Metabolic profile vs Differentially significant microbes

Image 2

Correlation coefficients:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
4C0d-2 0.1144 0.155 -0.0112 -0.0641 -0.1175 -0.0436 -0.1232 0.1393 -0.018 -0.1311 0.0414 0.1091
Actinobacteria 0.0958 0.2545 -0.0421 0.2138 0.2119 -0.0904 0.1804 0.0462 0.03 0.0037 0.0657 0.1695
Alphaproteobacteria -0.1695 -0.2645 -0.0297 0.0618 -0.0991 -0.0178 -0.0988 -0.106 0.0432 -0.1275 0.1757 0.4026
Bacilli -0.0594 -0.0575 0.2214 0.0186 0.0663 -0.0648 0.0544 -0.0586 -0.1782 0.074 -0.1224 0.2684
Bacteroidia -0.1523 -0.3057 -0.145 -0.2467 -0.1117 0.0712 -0.1084 -0.0537 -0.1585 -0.1242 -0.143 0.0852
Betaproteobacteria -0.0257 -0.0497 -0.2751 0.1463 -0.0136 0.0181 -0.0077 -0.0554 0.0133 -0.1255 0.1703 0.2759
Chloroplast 0.0715 0.3153 -0.1359 0.0468 0.3203 -0.036 0.324 -0.1405 0.1737 -0.1325 0.0319 -0.0547
Clostridia 0.2809 0.2378 -0.0752 -0.1598 -0.0299 -0.0255 -0.0193 0.0804 -0.0521 -0.0357 -0.2731 -0.0941
Coriobacteriia -0.0909 -0.159 0.0043 0.2375 -0.0015 0.1112 -0.0131 -0.0592 -0.2573 -0.0894 -0.1316 0.1873
Cytophagia 0.2402 0.1376 -0.285 -0.0759 0.0385 -0.0687 0.0393 0.0371 -0.0187 -0.0741 -0.1567 -0.1041
Deferribacteres 0.0478 0.2476 0.0194 0.0107 0.1424 -0.1261 0.1461 0.0261 -0.0448 0.0232 -0.2057 -0.0995
Deltaproteobacteria 0.1924 0.2219 -0.0644 0.0375 -0.0897 0.0913 -0.0769 -0.0883 -0.0413 -0.3728 -0.1239 -0.0233
Epsilonproteobacteria -0.1027 -0.1678 0.1556 -0.0215 -0.0437 0.1568 -0.0287 8e-04 0.025 0.17 -0.1187 0.1568
Erysipelotrichi -0.0024 -0.0766 -0.0813 -0.0455 -0.1475 0.1812 -0.1292 0.058 0.0305 -0.1633 0.0487 0.1391
Flavobacteriia -0.1047 -0.025 -0.0656 0.1748 -0.0302 -0.0836 -0.0422 -0.0936 -0.0158 -0.0318 0.1742 0.344
Gammaproteobacteria -0.0983 -0.1424 0.0088 0.0549 -0.1043 -0.2007 -0.1202 -0.1301 -0.0459 -0.034 0.0729 0.2949
Mollicutes 0.0768 0.0464 -0.0992 -0.1039 0.1907 -0.2133 0.161 0.2211 -0.1299 0.128 -0.2271 -0.0824
TM7-3 0.1602 0.0254 0.1299 0.031 -0.1599 0.1419 -0.1469 0.0503 -0.155 -0.012 -0.1529 -0.0685
Unclassified Unassigned -0.0551 -0.162 -0.0068 -0.1777 -0.1777 -0.1201 -0.1861 0.0977 -0.1277 0.0076 -0.0385 0.0388

P-values:

Body_Wt Subcutaneous_Fat_Wt Visceral_Fat_Wt Pancreas_Wt Insulin_ng_mL Blood_Glucose_mg_dL Real_HOMA_IR Serum_Acetate_ug_mL Serum_Butyrate_ng_mL Serum_Propionate_ng_mL Serum_Isovalerate_ng_mL Liver_Triglycerides_mg_dL
4C0d-2 0.3841 0.2371 0.9324 0.6264 0.3756 0.741 0.3525 0.2926 0.8926 0.3223 0.7553 0.4067
Actinobacteria 0.4667 0.0497 0.7497 0.101 0.1071 0.4924 0.1714 0.7282 0.8215 0.9778 0.6208 0.1953
Alphaproteobacteria 0.1954 0.0412 0.822 0.6393 0.4552 0.8927 0.4564 0.4242 0.7454 0.3359 0.1832 0.0014
Bacilli 0.6523 0.6624 0.0891 0.8878 0.6176 0.6227 0.6825 0.6593 0.177 0.5777 0.3559 0.0381
Bacteroidia 0.2453 0.0175 0.2689 0.0575 0.3994 0.5885 0.4137 0.686 0.2305 0.3486 0.2799 0.5175
Betaproteobacteria 0.8456 0.7063 0.0334 0.2647 0.9185 0.8908 0.9541 0.6766 0.9204 0.3434 0.1973 0.0328
Chloroplast 0.5871 0.0141 0.3006 0.7225 0.0134 0.7847 0.0123 0.2884 0.1882 0.3172 0.8105 0.678
Clostridia 0.0297 0.0673 0.5681 0.2226 0.8221 0.8466 0.8845 0.5451 0.6954 0.7884 0.0364 0.4746
Coriobacteriia 0.4895 0.225 0.9741 0.0676 0.9909 0.3976 0.9216 0.656 0.0491 0.5006 0.3203 0.1518
Cytophagia 0.0645 0.2944 0.0273 0.5644 0.7719 0.602 0.7675 0.7802 0.8883 0.5771 0.2358 0.4285
Deferribacteres 0.7167 0.0565 0.8832 0.9354 0.2819 0.337 0.2696 0.8444 0.7365 0.8614 0.118 0.4494
Deltaproteobacteria 0.1407 0.0884 0.6248 0.776 0.4992 0.4879 0.5626 0.506 0.756 0.0036 0.3497 0.8598
Epsilonproteobacteria 0.4347 0.2001 0.235 0.8702 0.7426 0.2314 0.8291 0.9952 0.8506 0.1979 0.3704 0.2314
Erysipelotrichi 0.9856 0.5607 0.5369 0.7302 0.2651 0.1658 0.3296 0.6628 0.8184 0.2164 0.7143 0.289
Flavobacteriia 0.426 0.8495 0.6187 0.1816 0.8205 0.5252 0.7511 0.4806 0.9057 0.8111 0.187 0.0071
Gammaproteobacteria 0.4551 0.2778 0.9468 0.6768 0.4318 0.1241 0.3645 0.3259 0.7301 0.798 0.5832 0.0222
Mollicutes 0.5598 0.725 0.4508 0.4296 0.1479 0.1017 0.2231 0.0923 0.3267 0.334 0.0836 0.5313
TM7-3 0.2213 0.8473 0.3225 0.814 0.2265 0.2793 0.2669 0.7053 0.2411 0.928 0.2476 0.6029
Unclassified Unassigned 0.6759 0.2161 0.9587 0.1744 0.1782 0.3607 0.1581 0.4617 0.335 0.9543 0.772 0.7688

Differentially significant microbes vs Differentially significant microbes

Image 3

Correlation coefficients:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia Deferribacteres Deltaproteobacteria Epsilonproteobacteria Erysipelotrichi Flavobacteriia Gammaproteobacteria Mollicutes TM7-3 Unclassified Unassigned
4C0d-2 1 0.1002 0.0248 0.0259 0.0553 -0.1394 -0.116 0.0024 -0.105 0.1356 -0.0756 0.0447 0.0418 0.0375 0.2007 -0.0199 0.0052 0.0809 -0.0643
Actinobacteria 0.1002 1 -0.1063 0.1755 -0.1003 -0.0336 0.0594 -0.0847 0.1137 0.0921 -0.0768 0.1982 -0.0639 0.3724 0.0361 -0.0449 0.0635 0.1079 0.1053
Alphaproteobacteria 0.0248 -0.1063 1 0.0234 -0.1022 0.0702 -0.0504 -0.01 0.0424 -0.1806 -0.0605 -0.1441 -0.0471 -0.0019 -0.0931 0.5558 -0.0803 -0.1082 0.0278
Bacilli 0.0259 0.1755 0.0234 1 0.2144 0.1534 0.0612 0.0869 0.2537 0.197 0.0345 0.08 -0.0443 0.1292 0.3436 0.1988 0.196 0.1238 0.3724
Bacteroidia 0.0553 -0.1003 -0.1022 0.2144 1 0.4964 -0.0801 -0.0577 0.2336 0.3036 -0.133 0.1545 0.0281 0.335 0.3136 -0.0143 -0.006 0.0446 0.4234
Betaproteobacteria -0.1394 -0.0336 0.0702 0.1534 0.4964 1 -0.0183 -0.0926 0.2932 0.1679 -0.1221 0.2033 -0.0831 0.2933 0.4903 0.0636 -0.0684 -0.1384 0.296
Chloroplast -0.116 0.0594 -0.0504 0.0612 -0.0801 -0.0183 1 0.3012 -0.1209 0.267 0.2634 0.2715 -0.0292 -0.079 -0.0589 -0.0681 0.053 -0.1752 -0.0726
Clostridia 0.0024 -0.0847 -0.01 0.0869 -0.0577 -0.0926 0.3012 1 0.0981 0.1751 0.6388 0.4327 0.0642 -0.0734 -0.0747 -0.0785 0.3392 -0.0273 -0.0406
Coriobacteriia -0.105 0.1137 0.0424 0.2537 0.2336 0.2932 -0.1209 0.0981 1 0.0331 0.0311 0.1639 0.0446 0.07 0.1762 0.0486 0.1292 0.0442 0.0463
Cytophagia 0.1356 0.0921 -0.1806 0.197 0.3036 0.1679 0.267 0.1751 0.0331 1 0.0844 0.3057 -0.1328 0.2642 0.0891 -0.0036 0.0529 0.0583 0.1784
Deferribacteres -0.0756 -0.0768 -0.0605 0.0345 -0.133 -0.1221 0.2634 0.6388 0.0311 0.0844 1 0.2824 -0.0052 -0.0583 -0.0978 -0.0266 0.1606 -0.0884 -0.0923
Deltaproteobacteria 0.0447 0.1982 -0.1441 0.08 0.1545 0.2033 0.2715 0.4327 0.1639 0.3057 0.2824 1 -0.0657 0.2706 -0.0468 -0.1475 -0.0374 0.0939 0.0274
Epsilonproteobacteria 0.0418 -0.0639 -0.0471 -0.0443 0.0281 -0.0831 -0.0292 0.0642 0.0446 -0.1328 -0.0052 -0.0657 1 0.0502 -0.0341 -0.047 -0.0715 0.2819 -0.0071
Erysipelotrichi 0.0375 0.3724 -0.0019 0.1292 0.335 0.2933 -0.079 -0.0734 0.07 0.2642 -0.0583 0.2706 0.0502 1 -0.0203 -0.0895 -0.0316 0.339 0.1518
Flavobacteriia 0.2007 0.0361 -0.0931 0.3436 0.3136 0.4903 -0.0589 -0.0747 0.1762 0.0891 -0.0978 -0.0468 -0.0341 -0.0203 1 0.0061 -0.1333 -0.1473 0.0581
Gammaproteobacteria -0.0199 -0.0449 0.5558 0.1988 -0.0143 0.0636 -0.0681 -0.0785 0.0486 -0.0036 -0.0266 -0.1475 -0.047 -0.0895 0.0061 1 0.0298 -0.1103 0.4022
Mollicutes 0.0052 0.0635 -0.0803 0.196 -0.006 -0.0684 0.053 0.3392 0.1292 0.0529 0.1606 -0.0374 -0.0715 -0.0316 -0.1333 0.0298 1 -0.0392 0.026
TM7-3 0.0809 0.1079 -0.1082 0.1238 0.0446 -0.1384 -0.1752 -0.0273 0.0442 0.0583 -0.0884 0.0939 0.2819 0.339 -0.1473 -0.1103 -0.0392 1 0.1128
Unclassified Unassigned -0.0643 0.1053 0.0278 0.3724 0.4234 0.296 -0.0726 -0.0406 0.0463 0.1784 -0.0923 0.0274 -0.0071 0.1518 0.0581 0.4022 0.026 0.1128 1

P-values:

4C0d-2 Actinobacteria Alphaproteobacteria Bacilli Bacteroidia Betaproteobacteria Chloroplast Clostridia Coriobacteriia Cytophagia Deferribacteres Deltaproteobacteria Epsilonproteobacteria Erysipelotrichi Flavobacteriia Gammaproteobacteria Mollicutes TM7-3 Unclassified Unassigned
4C0d-2 NA 0.4462 0.8509 0.8442 0.6746 0.288 0.3774 0.9855 0.4247 0.3015 0.566 0.7343 0.7512 0.7763 0.1242 0.88 0.9686 0.539 0.6253
Actinobacteria 0.4462 NA 0.4189 0.1798 0.4457 0.7988 0.6521 0.52 0.3869 0.4839 0.5598 0.129 0.6276 0.0034 0.7845 0.7334 0.6297 0.4117 0.4235
Alphaproteobacteria 0.8509 0.4189 NA 0.8591 0.4371 0.5938 0.7024 0.9395 0.748 0.1674 0.6459 0.2719 0.7205 0.9885 0.4792 0 0.542 0.4105 0.8331
Bacilli 0.8442 0.1798 0.8591 NA 0.1 0.242 0.6425 0.509 0.0504 0.1314 0.7935 0.5434 0.7366 0.3251 0.0072 0.1278 0.1334 0.3459 0.0034
Bacteroidia 0.6746 0.4457 0.4371 0.1 NA 1e-04 0.5431 0.6614 0.0724 0.0183 0.311 0.2385 0.831 0.0089 0.0147 0.9137 0.9635 0.7351 7e-04
Betaproteobacteria 0.288 0.7988 0.5938 0.242 1e-04 NA 0.8895 0.4815 0.023 0.1998 0.3526 0.1192 0.5279 0.0229 1e-04 0.6293 0.6035 0.2916 0.0217
Chloroplast 0.3774 0.6521 0.7024 0.6425 0.5431 0.8895 NA 0.0194 0.3575 0.0392 0.042 0.0358 0.8245 0.5485 0.655 0.6052 0.6873 0.1805 0.5812
Clostridia 0.9855 0.52 0.9395 0.509 0.6614 0.4815 0.0194 NA 0.456 0.181 0 6e-04 0.6263 0.577 0.5706 0.551 0.008 0.8357 0.7582
Coriobacteriia 0.4247 0.3869 0.748 0.0504 0.0724 0.023 0.3575 0.456 NA 0.8018 0.8137 0.2107 0.7352 0.5949 0.1781 0.7123 0.325 0.7373 0.7256
Cytophagia 0.3015 0.4839 0.1674 0.1314 0.0183 0.1998 0.0392 0.181 0.8018 NA 0.5215 0.0175 0.3118 0.0413 0.4983 0.9785 0.6881 0.6583 0.1726
Deferribacteres 0.566 0.5598 0.6459 0.7935 0.311 0.3526 0.042 0 0.8137 0.5215 NA 0.0288 0.9685 0.658 0.457 0.8402 0.2203 0.5019 0.4831
Deltaproteobacteria 0.7343 0.129 0.2719 0.5434 0.2385 0.1192 0.0358 6e-04 0.2107 0.0175 0.0288 NA 0.6178 0.0365 0.7223 0.2607 0.7769 0.4756 0.8356
Epsilonproteobacteria 0.7512 0.6276 0.7205 0.7366 0.831 0.5279 0.8245 0.6263 0.7352 0.3118 0.9685 0.6178 NA 0.7033 0.7958 0.7212 0.5873 0.0291 0.9573
Erysipelotrichi 0.7763 0.0034 0.9885 0.3251 0.0089 0.0229 0.5485 0.577 0.5949 0.0413 0.658 0.0365 0.7033 NA 0.8775 0.4966 0.8104 0.0081 0.247
Flavobacteriia 0.1242 0.7845 0.4792 0.0072 0.0147 1e-04 0.655 0.5706 0.1781 0.4983 0.457 0.7223 0.7958 0.8775 NA 0.9633 0.31 0.2615 0.6594
Gammaproteobacteria 0.88 0.7334 0 0.1278 0.9137 0.6293 0.6052 0.551 0.7123 0.9785 0.8402 0.2607 0.7212 0.4966 0.9633 NA 0.8212 0.4017 0.0014
Mollicutes 0.9686 0.6297 0.542 0.1334 0.9635 0.6035 0.6873 0.008 0.325 0.6881 0.2203 0.7769 0.5873 0.8104 0.31 0.8212 NA 0.7662 0.8434
TM7-3 0.539 0.4117 0.4105 0.3459 0.7351 0.2916 0.1805 0.8357 0.7373 0.6583 0.5019 0.4756 0.0291 0.0081 0.2615 0.4017 0.7662 NA 0.391
Unclassified Unassigned 0.6253 0.4235 0.8331 0.0034 7e-04 0.0217 0.5812 0.7582 0.7256 0.1726 0.4831 0.8356 0.9573 0.247 0.6594 0.0014 0.8434 0.391 NA